Stem cell treatment & Aortic aneurysm

Written based on 21 research studies on PubMed, searched on 14 Nov 2026.

The claim

Posts online say that stem cell treatment helps with aortic aneurysm.

Where research stands

We found 71 published papers on stem cell treatment and aortic aneurysm. They were published between 2006 and 2026. 1 of them is a study in people. 1 of them compared people who got it with a group that did not. 41 were studies in animals, and 10 were only in cells in the lab. 11 papers are reviews that sum up other studies. 1 new study in people is running or will start soon, say the trial registers. 3 research projects on stem cell treatment for aortic aneurysm are funded and still running.

• 1In people1 with a comparison group
• 41In animals
• 10Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Rationale and Design of the ARREST Trial Investigating Mesenchymal Stem Cells in the Treatment of Small Abdominal Aortic Aneurysm.2018 · Ann Vasc Surg · Randomised trial
2. The effect of drugs and stem cell therapies on established abdominal aortic aneurysms in mice: A systematic review and meta-analysis.2026 · Vascul Pharmacol · Review
3. Stem cell-based therapies for treatment of abdominal aortic aneurysm: development, application, and future potential.2025 · NPJ Biomed Innov · Review
4. Therapeutic efficacy of mesenchymal stem cells for abdominal aortic aneurysm: a meta-analysis of preclinical studies.2022 · Stem Cell Res Ther · Review
5. Regenerative potential of pluripotent nontumorgenetic stem cells: Multilineage differentiating stress enduring cells (Muse cells).2020 · Regen Ther · Review
6. Immunological therapeutics in acute aortic syndrome.2020 · Asian Cardiovasc Thorac Ann · Review
7. The Application of Induced Pluripotent Stem Cells in Pathogenesis Study and Gene Therapy for Vascular Disorders: Current Progress and Future Challenges.2019 · Stem Cells Int · Review
8. Sca1⁺ stem cells contribute to β-Aminopropionitrile-exacerbated aortic aneurysm progression in marfan syndrome.2026 · Heart Vessels · In animals
9. Cocktail Therapy Combining SGLT2 Inhibitor, Entresto, and Adipose-Derived Mesenchymal Stem Cells Prevents Abdominal Aortic Aneurysmal Complication Syndrome in Rodents.2026 · Acta Cardiol Sin · In animals
10. Targeting Abdominal Aortic Aneurysms with Multipotent Mesenchymal Stromal/Stem Cells: Insights into Immunological Effects.2026 · Curr Stem Cell Res Ther · In animals
11. Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence.2026 · Biomaterials · In animals
12. A Single Injection of ADRCs Does Not Prevent AAA Formation in Rats in a Randomized Blinded Design.2024 · Int J Mol Sci · In animals
13. Impact of adipose-derived stem cells on aortic tensile strength in a model of abdominal aortic aneurysm.2023 · Am Heart J Plus · In animals
14. Generation of induced pluripotent stem cell lines from patients with thoracic aortic aneurysm carrying the ACTA2 gene mutation.2025 · Stem Cell Res · In the lab
15. MTHFR variant links homocysteine metabolism and endothelial cell dysfunction by targeting mitophagy in human thoracic aortic dissection patient induced pluripotent stem cell (iPSC) models.2025 · J Adv Res · In the lab
16. Engineering a Human Pluripotent Stem Cell-Based in vitro Microphysiological System for Studying the Metformin Response in Aortic Smooth Muscle Cells.2021 · Front Bioeng Biotechnol · In the lab
17. Different Drugs Effect on Mesenchymal Stem Cells Isolated From Abdominal Aortic Aneurysm.2020 · Ann Vasc Surg · In the lab
18. Response to Shen et al to rapid communication "Fact or fiction: Exploring resident mesenchymal stem cells in abdominal aortic aneurysm from multiple perspectives".2026 · Genes Dis · Other paper
19. Correction: MicroRNA-19b-3p dysfunction of mesenchymal stem cell-derived exosomes from patients with abdominal aortic aneurysm impairs therapeutic efficacy.2025 · J Nanobiotechnology · Other paper
20. Fact or fiction - Exploring resident mesenchymal stem cells in abdominal aortic aneurysm from multiple perspectives.2025 · Genes Dis · Other paper
21. Therapeutic potential of mesenchymal stem cells and their secreted extracellular vesicles in thoracic aortic aneurysm disease.2024 · J Thorac Cardiovasc Surg · Other paper