Stem cell treatment & Chronic kidney disease

Written from the studies on PubMed, searched on 11 Nov 2026. Every number below comes from a study listed under Sources.

The claim

Posts online say that stem cell treatment helps with chronic kidney disease.

Where research stands

We found 168 published papers on stem cell treatment and chronic kidney disease. They were published between 2003 and 2026. 12 of them are studies in people. 5 of them compared people who got it with a group that did not. 37 were studies in animals, and 4 were only in cells in the lab. 75 papers are reviews that sum up other studies. 15 new studies in people are running or will start soon, says the trial register ClinicalTrials.gov.

• 12In people5 with a comparison group
• 37In animals
• 4Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Clinical efficacy and safety of allogeneic adipose-derived stem cells ELIXCYTE in chronic kidney disease: a phase I/II study.2026 · Stem Cells Transl Med · Randomised trial
2. Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson's disease clinical trial.2025 · Stem Cell Res Ther · Randomised trial
3. Mitigation of late renal and pulmonary injury after hematopoietic stem cell transplantation.2012 · Int J Radiat Oncol Biol Phys · Randomised trial
4. Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial.2008 · Int J Radiat Oncol Biol Phys · Randomised trial
5. A strategy to achieve donor-specific hyporesponsiveness in cadaver renal allograft recipients by donor haematopoietic stem cell transplantation into the thymus and periphery.2004 · Nephrol Dial Transplant · Randomised trial
6. Allogeneic adipose tissue-derived stem cells ELIXCYTE® in chronic kidney disease: A phase I study assessing safety and clinical feasibility.2022 · J Cell Mol Med · Study in people
7. Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical Siblings.2022 · Front Immunol · Study in people
8. Bone marrow-mesenchymal stromal cell infusion in patients with chronic kidney disease: A safety study with 18 months of follow-up.2018 · Cytotherapy · Study in people
9. Risk assessment of tuberculosis in immunocompromised patients. A TBNET study.2014 · Am J Respir Crit Care Med · Study in people
10. Mesenchymal stromal cells and kidney transplantation: pretransplant infusion protects from graft dysfunction while fostering immunoregulation.2013 · Transpl Int · Study in people
11. Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility.2011 · Clin J Am Soc Nephrol · Study in people
12. Translating Mesenchymal Stem Cell Research into Chronic Kidney Disease Therapy: A Systematic and Clinical Review.2026 · Iran Biomed J · Review
13. Urine-Derived Stem Cells: Challenges in Isolation, Biological Identity, and Therapeutic Potential in CKD-Associated Fibrosis.2026 · Int J Mol Sci · Review
14. Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles as Antifibrotic Nanotherapeutics for Chronic Kidney Disease.2026 · Adv Healthc Mater · Review
15. Cell based therapy in chronic kidney disease: emerging evidence for a fifth pillar in guideline directed medical therapy.2026 · Clin Exp Nephrol · Review
16. Urine-derived stem cells in kidney disease: progress, challenges, and future directions.2026 · Stem Cell Res Ther · Review
17. Mesenchymal/stromal cell therapy in kidney diseases: an update.2026 · Curr Opin Nephrol Hypertens · Review
18. Elevated asymmetric dimethylarginine drives hematopoietic stem cell metabolic reprogramming and dysfunction in chronic kidney disease.2026 · Exp Cell Res · In animals
19. Mesenchymal stem cells and empagliflozin: a potential therapeutic approach for autophagy and Klotho modulation in diabetic kidney disease.2026 · Stem Cells · In animals
20. Distinct Temporal Modulation of Mesenchymal Stem Cells and Empagliflozin on Renal c-Kit Cells in Diabetic Kidney Disease.2026 · Front Biosci (Landmark Ed) · In animals
21. Human adipose-derived mesenchymal stem cells ameliorate Diabetic Kidney Disease by restoring macrophage efferocytosis.2026 · Stem Cell Res Ther · In animals
22. Dual-targeted engineered mesenchymal stem cell-derived extracellular vesicles delivering Nedd4 attenuate renal fibrosis in diabetic kidney disease.2026 · Mater Today Bio · In animals
23. Mesenchymal Stem Cell and Secretome Treatments Inhibit the mTOR-NOX4 Pathway in Diabetic Kidney Disease.2026 · Diabetes · In animals
24. Generation of a human induced pluripotent stem cell line (UMGACBi001-A) from urine cells of a chronic kidney disease patient with hypertension, diabetic nephropathy and acute sepsis.2023 · Stem Cell Res · In the lab
25. The Use of 99mTc-Labeled Stem Cells for Evaluation of Chronic Kidney Disease.2023 · Methods Mol Biol · In the lab
26. Pioglitazone Improves the Function of Human Mesenchymal Stem Cells in Chronic Kidney Disease Patients.2019 · Int J Mol Sci · In the lab
27. Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease.2013 · EMBO Mol Med · In the lab
28. Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe chronic kidney disease in a dog.2026 · Front Vet Sci · Other paper
29. Mesenchymal stem cells in diabetic kidney disease: Potential regulatory mechanisms and related signaling pathways of mesenchymal stem cells.2026 · Chin Med J (Engl) · Other paper
30. Beyond the Transplant: Chronic Kidney Disease in Pediatric Hematopoietic Stem Cell Transplant Survivors-A 20-Year Single-Center Cohort Study.2026 · Pediatr Transplant · Other paper
31. Systemic mesenchymal stem cell therapy for reduction of inflammatory burden in a patient with juvenile-onset rheumatoid arthritis and dialysis-dependent renal failure.2026 · Croat Med J · Other paper

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