Stem cell treatment & Congenital heart disease

Written based on 16 research studies on PubMed, searched on 14 Nov 2026.

The claim

Posts online say that stem cell treatment helps with congenital heart disease.

Where research stands

We found 51 published papers on stem cell treatment and congenital heart disease. They were published between 2008 and 2026. None of them is a study in people. 2 were studies in animals, and 10 were only in cells in the lab. 21 papers are reviews that sum up other studies. 2 new studies in people are running or will start soon, say the trial registers. 14 research projects on stem cell treatment for congenital heart disease are funded and still running.

• 0In people
• 2In animals
• 10Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Unproven means: it was only tested in animals or cells, or there is too little or mixed data from people. How we rate claims

Sources

1. Stem Cell and Gene Therapies in Congenital Heart Disease: A Systematic Review.2026 · Curr Cardiol Rev · Review
2. Advancing Congenital Heart Defect Treatments: Synergistic Approaches with Stem Cells and Functional Scaffolds.2026 · Stem Cell Rev Rep · Review
3. Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease.2025 · Mol Cell Biochem · Review
4. Unlocking the potential of induced pluripotent stem cells for neonatal disease modeling and drug development.2023 · Semin Perinatol · Review
5. Induced Pluripotent Stem Cell-Based Modeling of Single-Ventricle Congenital Heart Diseases.2023 · Curr Cardiol Rep · Review
6. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies.2022 · Birth Defects Res · Review
7. Deciphering Congenital Heart Disease Using Human Induced Pluripotent Stem Cells.2024 · Adv Exp Med Biol · In animals
8. Wharton's Jelly-Mesenchymal Stem Cell-Engineered Conduit for Pediatric Translation in Heart Defect.2021 · Tissue Eng Part A · In animals
9. Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells Provides Insights Into Cardiovascular Disease Pathogenesis.2025 · J Am Heart Assoc · In the lab
10. Establishment of a human induced pluripotent stem cell line, KMUGMCi008-A, from a patient with A Say-Barber-Biesecker-Young-Simpson variant of Ohdo syndrome bearing heterozygous frameshift mutation in the KAT6B gene.2025 · Stem Cell Res · In the lab
11. Establishment of human pluripotent stem cell-derived cortical neurosphere model to study pathomechanisms and chemical toxicity in Kleefstra syndrome.2024 · Sci Rep · In the lab
12. Generation and characterization of a human induced pluripotent stem cell line heterozygous for a NOTCH1 mutation (NCHi014-A).2024 · Stem Cell Res · In the lab
13. Hematopoietic Stem Cell Transplantation in a Fontan Patient With Myelodysplastic Syndrome.2026 · JACC Case Rep · Other paper
14. Generation of three induced pluripotent stem cell clones from a functional single ventricle patient carrying the BRAF c.1897 T > C variant.2026 · Stem Cell Res · Other paper
15. Eight-Year Outcomes of Cardiosphere-Derived Cells in Single Ventricle Congenital Heart Disease.2024 · J Am Heart Assoc · Other paper
16. Generation of an induced pluripotent stem cell line (NCHi016-A) from a 5-year-old female with pulmonary atresia with intact ventricular septum and one-and-half ventricle palliation.2024 · Stem Cell Res · Other paper