Stem cell treatment & Cystic fibrosis

Written based on 19 research studies on PubMed, searched on 11 Nov 2026.

The claim

Posts online say that stem cell treatment helps with cystic fibrosis.

Where research stands

We found 51 published papers on stem cell treatment and cystic fibrosis. They were published between 2006 and 2026. 1 of them is a study in people. None of them compared people who got it with a group that did not. 4 were studies in animals, and 14 were only in cells in the lab. 20 papers are reviews that sum up other studies. 1 new study in people is running or will start soon, say the trial registers. 16 research projects on stem cell treatment for cystic fibrosis are funded and still running.

• 1In people
• 4In animals
• 14Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. A phase I study assessing the safety and tolerability of allogeneic mesenchymal stem cell infusion in adults with cystic fibrosis.2023 · J Cyst Fibros · Study in people
2. Progress towards regenerative therapies for the cystic fibrosis lung and pancreas: insights from stem cells and organoids.2026 · J Cyst Fibros · Review
3. Human mesenchymal stem cell therapy: Potential advances for reducing cystic fibrosis infection and organ inflammation.2025 · Best Pract Res Clin Haematol · Review
4. Advancing the Battle against Cystic Fibrosis: Stem Cell and Gene Therapy Insights.2024 · Curr Med Sci · Review
5. Modeling of Respiratory Diseases Evolving with Fibrosis from Organoids Derived from Human Pluripotent Stem Cells.2023 · Int J Mol Sci · Review
6. Correction of Airway Stem Cells: Genome Editing Approaches for the Treatment of Cystic Fibrosis.2020 · Hum Gene Ther · Review
7. Cell-Based Therapeutic Approaches for Cystic Fibrosis.2020 · Int J Mol Sci · Review
8. Basal cell transplantation supports multilineage differentiation and restores CFTR function in ex vivo ferret airways.2026 · JCI Insight · In animals
9. Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease.2024 · Sci Rep · In animals
10. Human Mesenchymal Stem Cell (hMSC) Donor Potency Selection for the "First in Cystic Fibrosis" Phase I Clinical Trial (CEASE-CF).2023 · Pharmaceuticals (Basel) · In animals
11. Mesenchymal Stem Cell Soluble Mediators and Cystic Fibrosis.2017 · J Stem Cell Res Ther · In animals
12. Immune Modulation in Peripheral Blood of Cystic Fibrosis Patients Following Ex Vivo Co-Culture with Mesenchymal Stem Cells.2026 · Cells · In the lab
13. Establishment and characterization of an induced pluripotent stem cell line from a Japanese cystic fibrosis patient with homozygous 1540del10 CFTR mutation.2025 · Genes Dis · In the lab
14. Generation of human-induced pluripotent stem cells from a patient with homozygous I1234V mutation of cystic fibrosis.2024 · Qatar Med J · In the lab
15. Generation of an induced pluripotent stem cell line (IGGi002A) from nasal cells of a cystic fibrosis patient homozygous for the G542X-CFTR mutation.2023 · Stem Cell Res · In the lab
16. Modeling Cystic Fibrosis Patient-Specific Responses to CFTR Modulators Using Human Induced Pluripotent Stem Cells.2025 · Am J Respir Crit Care Med · Other paper
17. In vivo editing of lung stem cells for durable gene correction in mice.2024 · Science · Other paper
18. Cystic Fibrosis Airways: Does Disease Stem from Faulty Stem Cells?2023 · Am J Respir Crit Care Med · Other paper
19. Differentiation and Characterization of Cystic Fibrosis Transmembrane Conductance Regulator Knockout Human Pluripotent Stem Cells into Salivary Gland Epithelial Progenitors.2023 · Int J Stem Cells · Other paper