Stem cell treatment & Multiple system atrophy

Written based on 23 research studies on PubMed, searched on 14 Nov 2026.

The claim

Posts online say that stem cell treatment helps with multiple system atrophy.

Where research stands

We found 32 published papers on stem cell treatment and multiple system atrophy. They were published between 2002 and 2026. 4 of them are studies in people. 3 of them compared people who got it with a group that did not. 9 were studies in animals, and 3 were only in cells in the lab. 7 papers are reviews that sum up other studies. 6 new studies in people are running or will start soon, say the trial registers. 1 research project on stem cell treatment for multiple system atrophy is funded and still running.

• 4In people3 with a comparison group
• 9In animals
• 3Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy.2019 · Neurology · Randomised trial
2. A randomized trial of mesenchymal stem cells in multiple system atrophy.2012 · Ann Neurol · Randomised trial
3. Autologous mesenchymal stem cell therapy delays the progression of neurological deficits in patients with multiple system atrophy.2008 · Clin Pharmacol Ther · Randomised trial
4. Phase I Trial of Intra-arterial Administration of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Multiple System Atrophy.2021 · Stem Cells Int · Study in people
5. Safety and Efficacy of Mesenchymal Stem Cell Therapy in Multiple System Atrophy: Systematic Review.2026 · Biologics · Review
6. Mesenchymal stem cells modulate misfolded α-synuclein in parkinsonian disorders: A multitarget disease-modifying strategy.2020 · Stem Cell Res · Review
7. Induced pluripotent stem cells in multiple system atrophy: recent developments and scientific challenges.2019 · Clin Auton Res · Review
8. Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases.2019 · Mayo Clin Proc · Review
9. Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease.2018 · Front Neurosci · Review
10. In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells.2018 · J Cell Mol Med · Review
11. Transplantation of Adipose-Derived Stem Cells Alleviates Striatal Degeneration in a Transgenic Mouse Model for Multiple System Atrophy.2020 · Cell Transplant · In animals
12. Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages.2020 · Stem Cell Res Ther · In animals
13. Feasibility and Efficacy of Intra-Arterial Administration of Mesenchymal Stem Cells in an Animal Model of Double Toxin-Induced Multiple System Atrophy.2017 · Stem Cells Transl Med · In animals
14. Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.2016 · Acta Neuropathol · In animals
15. A safety study on intrathecal delivery of autologous mesenchymal stromal cells in rabbits directly supporting Phase I human trials.2015 · Transfusion · In animals
16. Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotection.2011 · PLoS One · In animals
17. Generation of an induced pluripotent stem cell line (NIMHi28-A) from a parkinsonian-type multiple system atrophy patient of Indian origin.2026 · Stem Cell Res · In the lab
18. Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts.2026 · Front Immunol · In the lab
19. Creation of a library of induced pluripotent stem cells from Parkinsonian patients.2016 · NPJ Parkinsons Dis · In the lab
20. Editorial Expression of Concern: Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages.2025 · Stem Cell Res Ther · Other paper
21. Comment: Autologous mesenchymal stem cells: Hope for patients with multiple system atrophy?2019 · Neurology · Other paper
22. Mesenchymal stem cells can modulate longitudinal changes in cortical thickness and its related cognitive decline in patients with multiple system atrophy.2014 · Front Aging Neurosci · Other paper
23. Preliminary report of multiple cell therapy for patients with multiple system atrophy.2013 · Cell Transplant · Other paper