Stem cell treatment & Ventricular tachycardia

Written based on 22 research studies on PubMed, searched on 13 Nov 2026.

The claim

Posts online say that stem cell treatment helps with ventricular tachycardia.

Where research stands

We found 52 published papers on stem cell treatment and ventricular tachycardia. They were published between 2007 and 2026. 1 of them is a study in people. 1 of them compared people who got it with a group that did not. 11 were studies in animals, and 16 were only in cells in the lab. 8 papers are reviews that sum up other studies. 1 paper was retracted. 6 research projects on stem cell treatment for ventricular tachycardia are funded and still running.

• 1In people1 with a comparison group
• 11In animals
• 16Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Intramyocardial injection of allogeneic human induced pluripotent stem cell-derived cardiomyocytes in advanced ischemic heart failure: an early-stage randomized trial.2026 · Nat Med · Randomised trial
2. Induced Pluripotent Stem Cells in Congenital Long QT Syndrome: Research Progress and Clinical Applications.2025 · Rev Cardiovasc Med · Review
3. The Role of Human-Induced Pluripotent Stem Cells in Studying Cardiac Channelopathies.2024 · Int J Mol Sci · Review
4. The Pathogenic Mechanisms of and Novel Therapies for Lamin A/C-Related Dilated Cardiomyopathy Based on Patient-Specific Pluripotent Stem Cell Platforms and Animal Models.2024 · Pharmaceuticals (Basel) · Review
5. Patient Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Development and Screening In Catecholaminergic Polymorphic Ventricular Tachycardia.2016 · J Atr Fibrillation · Review
6. Calcium signaling in human stem cell-derived cardiomyocytes: Evidence from normal subjects and CPVT afflicted patients.2016 · Cell Calcium · Review
7. Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes.2015 · Circ Res · Review
8. Accelerated Intrinsic Beating Rate in Heterogeneously Coupled Human Pluripotent Stem Cell-Derived Cardiomyocytes Can Underlie Focal Ventricular Tachycardia in Regenerative Therapy.2026 · J Precis Med (Amst) · In animals
9. Population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection.2025 · J Mol Cell Cardiol · In animals
10. Mesenchymal Stem Cells Increase Resistance Against Ventricular Arrhythmias Provoked in Rats with Myocardial Infarction.2024 · Stem Cell Rev Rep · In animals
11. Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias.2024 · Front Cardiovasc Med · In animals
12. Effects of Mesenchymal Stem Cell Injection into Healed Myocardial Infarction Scar Border Zone on the Risk of Ventricular Tachycardia.2023 · Biomedicines · In animals
13. Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs.2023 · NPJ Regen Med · In animals
14. Generation of a human induced pluripotent stem cell line (KSCBi016-A) from a CPVT patient with an RYR2 mutation.2024 · Stem Cell Res · In the lab
15. Generation of human induced pluripotent stem cell lines from patients with a RYR2 gene variant c.14201A>G (p.Y4734C): Implications for idiopathic ventricular fibrillation and catecholaminergic polymorphic ventricular tachycardia.2024 · Stem Cell Res · In the lab
16. Generation of two induced pluripotent stem cell lines from catecholaminergic polymorphic ventricular tachycardia patients carrying RYR2 mutations.2023 · Stem Cell Res · In the lab
17. Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.2023 · Circ Arrhythm Electrophysiol · In the lab
18. The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction.2011 · Circ Res · RetractedRetracted
19. Computational Simulations Show Proof-of-Concept for Optogenetic Suppression of Ectopic Activity in Cardiac Stem Cell Therapy.2025 · Cardiovasc Eng Technol · Other paper
20. Generation of an isogenic CRISPR/Cas9-corrected control induced pluripotent stem cell line from a patient with autosomal dominant catecholaminergic polymorphic ventricular tachycardia with a heterozygous variant in cardiac calsequestrin-2.2025 · Stem Cell Res · Other paper
21. Cardiovascular Events After Hematopoietic Stem Cell Transplant: Incidence and Risk Factors.2023 · JACC CardioOncol · Other paper
22. Patient-specific induced pluripotent stem cell properties implicate Ca2+-homeostasis in clinical arrhythmia associated with combined heterozygous RYR2 and SCN10A variants.2023 · Philos Trans R Soc Lond B Biol Sci · Other paper