Impact of preprocedural frailty on long-term mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis.

What was studied

This work looked at people with aortic stenosis who had TAVR. TAVR is a procedure to replace the aortic valve. The team asked if being frail before TAVR was linked to death later on. They searched large research databases up to 15 February 2026. Then they joined the results of past studies that followed groups of patients.

What they found

The review included 429,827 people in all. Results from 8 studies, with 4,726 people, were joined together. Frail people had a higher long-term risk of death from any cause. The link looked much the same across follow-up lengths and frailty tests. The other studies pointed the same way. In some, more frailty went with a higher risk of death.

What it means for patients

In older adults, frailty before TAVR was linked to more deaths later. The authors say frailty tests should be part of routine checks before TAVR. They also say these tests can help care teams make choices together.

Why it is not certain yet

This kind of study shows a link, not that frailty causes death. Only 8 of the studies could be joined in the main sum. The other studies gave results in forms that could not be joined. The studies measured frailty in different ways. The abstract does not say how the quality checks turned out.

Source

Impact of preprocedural frailty on long-term mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis.

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