Neuroimaging Studies of Bipolar Disorder With Suicide Attempts: A Systematic Review.

What was studied

This review gathered brain imaging studies of bipolar disorder with suicide attempts. It searched PubMed and Web of Science. The studies ran from 1990 to 2026. It looked at the brain's structure and function in suicide attempts.

What they found

Scans showed less gray matter in front and edge brain areas. Findings on cerebellum size were mixed. Fiber tracts showed signs of weak links. Lower values went with impulsivity and suicidal intent. Functional scans showed more activity in emotion areas. They showed less activity in front areas. Brain networks also showed altered connections.

What it means for patients

The authors say the findings fit one model. In it, weak brain structure and function disrupt control of emotion and behavior. This may help move from suicidal thoughts to suicidal acts. They say imaging findings may be candidate markers.

Why it is not certain yet

The authors say prospective validation is needed. This must come before any marker guides risk sorting or prevention. Findings on cerebellar volume were inconsistent. The review searched only PubMed and Web of Science. The abstract does not give how many studies it included.

Source

Neuroimaging Studies of Bipolar Disorder With Suicide Attempts: A Systematic Review.

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