Energetic metabolism in bipolar disorder: from markers to precision therapeutics.

What was studied

This review looked at energy metabolism in bipolar disorder. That is a mood illness with repeated episodes. The authors searched several databases. They included human studies and meta-analyses. They linked brain scan findings and blood markers. They also looked at new treatment ideas.

What they found

Studies often showed weak energy use in cells. ATP and phosphocreatine were lower. Brain scans showed signs of an energy shortfall. Lactate was higher. Blood markers of oxidative stress and inflammation were higher. Some markers of cell energy parts were lower.

What it means for patients

The authors say poor energy balance may add to bipolar disorder. They say brain scans and blood markers could help sort patients. This could guide care aimed at restoring energy balance. They list ideas such as creatine, CoQ10 and a ketogenic diet.

Why it is not certain yet

The authors say the evidence only suggests a role. They say large standard multicenter studies are needed. The review left out studies in children. It left out studies not in English. It does not give the number of studies.

Source

Energetic metabolism in bipolar disorder: from markers to precision therapeutics.

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