Predicting outcomes in locally advanced cervical cancer treated with radiotherapy: a systematic review of nomograms.

What was studied

This systematic review looked at nomograms for locally advanced cervical cancer (LACC). A nomogram is a tool that predicts outcomes. These tools were built for women treated with radiotherapy or chemoradiotherapy. The authors searched several databases for studies from 2010 to 2025. They checked how well the tools predict. They also checked which factors the tools use. They looked at how the tools were tested.

What they found

Several studies built tools for overall survival. Fewer looked at disease progression. The C-index ranged from 0.68 to 0.835. This shows moderate to good ability to tell outcomes apart. Lymph node status, tumor size and FIGO stage were used most often. Histology and SCC-Ag also appeared often. Tests in independent groups of patients were limited.

What it means for patients

The authors say these tools show moderate-to-good prediction. They say mixed methods, incomplete testing and changing treatments limit wider use. They say better outside testing is needed before clinical use.

Why it is not certain yet

Few tools were tested in independent groups of patients. Methods varied between studies. Treatments are changing, so older tools may not fit current care. A review can only be as good as the studies in it.

Source

Predicting outcomes in locally advanced cervical cancer treated with radiotherapy: a systematic review of nomograms.

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