Efficacy of Histaglobulin in Allergic Diseases: A Systematic Review and Meta-Analysis with Implications for Allergic Rhinitis.

What was studied

This meta-analysis looked at histaglobulin in allergic diseases. It is a mix of histamine and antibody proteins. It is given under the skin. It has been used for decades. Its uses include allergic rhinitis and chronic urticaria. The authors searched several databases from the start to March 2026. They included studies with 754 patients in all.

What they found

Studies in chronic urticaria had 190 patients. All used a before-after design with no control group. The pooled effect was large, with a Hedges g of 2.82. The range was 1.75-3.88. Results varied very widely between studies. A check that left out one study gave a similar result. Studies in allergic rhinitis had 165 patients. All reported clear symptom gains. Blood allergy markers returned to normal. No serious adverse events were found.

What it means for patients

The authors say histaglobulin may lower disease activity in chronic urticaria. They say the estimate shows gain after treatment, not a controlled effect. They say early evidence hints at a benefit in allergic rhinitis. They say randomized trials are needed.

Why it is not certain yet

Those studies had no control group. Confidence in the effect remains limited. The data on rhinitis are few and mixed. The total sample is too small to rule out rare or long-term side effects.

Source

Efficacy of Histaglobulin in Allergic Diseases: A Systematic Review and Meta-Analysis with Implications for Allergic Rhinitis.

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