Icahn School of Medicine at Mount Sinai
New York, United States
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Crohn's disease
Cure status
- AfimkibartPhase 3 · NCT06819891 · NCT07298421 · NCT06819878 · NCT05910528
- AZA capsulesPhase 3 · NCT05040464
- DuvakitugPhase 3 · NCT07184931 · NCT07184944 · NCT07923383
- Fecal Microbiota Transplantation (FMT)Phase 3 · NCT04997733
- FluconazolePhase 3 · NCT06274554
- GuselkumabPhase 3 · NCT05242471 · NCT07577843 · NCT03466411 · NCT07499232 · NCT06663332 · NCT05347095 · NCT05923073 · NCT06408935
- Guselkumab Dose 1Phase 3 · NCT03466411 · NCT05197049
- Guselkumab Dose 2Phase 3 · NCT03466411 · NCT05197049
- Guselkumab Dose 3Phase 3 · NCT03466411 · NCT05197049
- IL-23 TherapyPhase 3 · NCT06274554
- Immunosuppressive AgentsPhase 3 · NCT06059989
- Infliximab subcutaneousPhase 3 · NCT06059989
- IV TulisokibartPhase 3 · NCT06430801
- JNJ-78934804Phase 3 · NCT05242471 · NCT07577843
- MirikizumabPhase 3 · NCT05509777 · NCT06937099 · NCT04844606 · NCT04232553
- MTXPhase 3 · NCT05040464
- RisankizumabPhase 3 · NCT05995353 · NCT07697456 · NCT07499232 · NCT04524611 · NCT07177118 · NCT06548542
- Risankizumab IVPhase 3 · NCT03105102
- Risankizumab On-Body Injector (OBI)Phase 3 · NCT03105102
- Risankizumab SCPhase 3 · NCT03105102 · NCT06063967
- SC TulisokibartPhase 3 · NCT06430801
- TirzepatidePhase 3 · NCT06976853 · NCT06937099
- TulisokibartPhase 3 · NCT06651281
- UpadacitinibPhase 3 · NCT07149467 · NCT06227910 · NCT06332534 · NCT03345823 · NCT06902987
- UstekinumabPhase 3 · NCT03167437 · NCT05092269 · NCT03466411 · NCT04524611 · NCT07177118 · NCT05725876
- Ustekinumab (approximately 6 mg/kg)Phase 3 · NCT07149467
- VedolizumabPhase 3 · NCT04738942 · NCT06227910 · NCT03219359
- Vedolizumab IVPhase 3 · NCT05837897 · NCT05442567 · NCT06100289 · NCT04779320
- Vedolizumab SCPhase 3 · NCT06100289 · NCT06405087
- budesonidePhase 2/3 · NCT06719622
- Guselkumab Dose 4Phase 2/3 · NCT03466411
- Guselkumab Dose 5Phase 2/3 · NCT03466411
- IcotrokinraPhase 2/3 · NCT07196722
- InfliximabPhase 2/3 · NCT05660746
- ModafinilPhase 2/3 · NCT07582458 · NCT07295834
- omeprazole (proton pump inhibitor)Phase 2/3 · NCT06719622
- RoadMABPhase 2/3 · NCT05660746
- 0.9% sodium chloridePhase 2 · NCT07077746
- ABBV-701Phase 2 · NCT07697456
- ABBV-8736Phase 2 · NCT06548542
- Adalimumab-800CWPhase 2 · NCT03938701
- AlemtuzumabPhase 2 · NCT00692939 · NCT01962415
- AmitriptylinePhase 2 · NCT07556718
- anti-TL1A monoclonal antibody, high dosePhase 2 · NCT07078994
- anti-TL1A monoclonal antibody, low dosePhase 2 · NCT07078994
- anti-TL1A monoclonal antibody, medium dosePhase 2 · NCT07078994
- AZD7798Phase 2 · NCT06450197 · NCT06681324
- Azithromycin PillPhase 2 · NCT05599347
- brivekimigPhase 2 · NCT06958536
- CyclophosphamidePhase 2 · NCT06721962 · NCT04224558 · NCT00692939 · NCT03219359
- DB-3QPhase 2 · NCT07625293 · NCT06918808
- Faecal microbiota transplantationPhase 2 · NCT04924270
- FludarabinePhase 2 · NCT04224558 · NCT01962415
- GolimumabPhase 2 · NCT05242471
- H021 Enteric-coated Tablets High-dose GroupPhase 2 · NCT07677514
- H021 Enteric-coated Tablets Low-dose GroupPhase 2 · NCT07677514
- HB-adMSCs - Hope Biosciences Adipose Derived Mesenchymal Stem CellsPhase 2 · NCT07077746
- High DosePhase 2 · NCT07832435
- HydroxyureaPhase 2 · NCT01962415
- L2-01 adipose-derived mesenchymal stem cells (MSC)Phase 2 · NCT07010926
- local co-administration of autologous ADIposePhase 2 · NCT04010526
- Low DosePhase 2 · NCT07832435
- LutikizumabPhase 2 · NCT06548542
- LY4395089Phase 2 · NCT07483099 · NCT07483073
- MelphalanPhase 2 · NCT00692939 · NCT06986382 · NCT01962415
- MethylprednisolonePhase 2 · NCT04224558 · NCT03219359
- Mirikizumab - Intravenous (IV)Phase 2 · NCT07483099 · NCT07483073
- Mirikizumab - Subcutaneous (SC)Phase 2 · NCT07483099 · NCT07483073
- MORF-057Phase 2 · NCT06226883
- MT-201Phase 2 · NCT07113522
- MT-501Phase 2 · NCT07113522
- MTP-101CPhase 2 · NCT06631586
- MTP-101SPhase 2 · NCT06631586
- N-Acetylglucosamine (GlcNAc)Phase 2 · NCT07225998
- ObefazimodPhase 2 · NCT06456593
- OntunisertibPhase 2 · NCT07683325
- PrednisolonePhase 2 · NCT06953791
- SL-325Phase 2 · NCT07753850
- TAK-279Phase 2 · NCT06233461
- TEV-48574 Dose Regimen APhase 2 · NCT05668013
- TEV-48574 Dose Regiment BPhase 2 · NCT05668013
- ThiotepaPhase 2 · NCT00692939 · NCT01962415
- ThymoglobulinPhase 2 · NCT03219359
- TRA16Phase 2 · NCT07871669
- TrosunilimabPhase 2 · NCT07697456 · NCT06548542
- Vancomycin /Amphotericin B (Fungizone®) /Gentamicine 80 mgPhase 2 · NCT07300553
- XanthohumolPhase 2 · NCT04590508
- ZasocitinibPhase 2 · NCT07403968 · NCT06764615
- 25mg adalimumab-680LT and 15/25 mg risankizumab-800CWPhase 1/2 · NCT07258641
- AcetaminophenPhase 1/2 · NCT04224558
- Adalimumab-680LT 25mgPhase 1/2 · NCT07258641
- AdMSC (CellReady®)Phase 1/2 · NCT06636032
- anti-thymocyte globulin (rabbit)Phase 1/2 · NCT04224558
- AntibioticsPhase 1/2 · NCT04970446
- ATGPhase 1/2 · NCT00692939 · NCT06986382
- autologous CD34-selected peripheral blood stem cells transplantPhase 1/2 · NCT00692939
- Bacteriophage preparationPhase 1/2 · NCT03808103
- CliniMACS® TCR α/β Reagent Kit and CliniMACS® CD19 SystemPhase 1/2 · NCT06986382
- ClofarabinePhase 1/2 · NCT06986382
- CytoxanPhase 1/2 · NCT04224558
- DiphenhydraminePhase 1/2 · NCT04224558
- FilgrastimPhase 1/2 · NCT04224558
- FMTPhase 1/2 · NCT04970446
- G-CSFPhase 1/2 · NCT00692939
- ICG318, BCMA-CD19-IL-15/IL-15 sushi Compound CAR TPhase 1/2 · NCT07544160
- injection of thawed SVFPhase 1/2 · NCT07629245
- Interleukin-2 (aldesleukin).Phase 1/2 · NCT04263831
- lymphocyte immune globulinPhase 1/2 · NCT04224558
- Mesenchymal Stromal CellsPhase 1/2 · NCT03901235
- MesnaPhase 1/2 · NCT04224558 · NCT00692939
- Oxygen Gas for InhalationPhase 1/2 · NCT06109961
- PaliferminPhase 1/2 · NCT06986382
- Peripheral Blood Stem Cell InfusionPhase 1/2 · NCT04224558
- Prednisone/MethylprenisolonePhase 1/2 · NCT06986382
- Risankizumab-800CWPhase 1/2 · NCT06606808 · NCT07258641
- Risankizumab-800CW optimal dosePhase 1/2 · NCT06606808
- RituximabPhase 1/2 · NCT00692939 · NCT06986382
- Total Body IrradiationPhase 1/2 · NCT06986382
- TRX103Phase 1/2 · NCT06721962
- VorinostatPhase 1/2 · NCT03167437
- 24mg bid TQH3906 capsulePhase 1 · NCT06754891
- 32mg TQH3906 capsulePhase 1 · NCT06754891
- Autologous Adult Stem Cell-Derived Intestinal OrganoidPhase 1 · NCT07822087
- CabozantinibPhase 1 · NCT03816345
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cellsPhase 1 · NCT05003947
- EBFAHF-2Phase 1 · NCT03992469
- Fecal Microbiota TransplantPhase 1 · NCT02636517
- FluoropyrimidinePhase 1 · NCT03816345
- injection of CNK-UT009Phase 1 · NCT07416383
- IpilimumabPhase 1 · NCT03816345
- NivolumabPhase 1 · NCT03816345
- PALI-2108Phase 1 · NCT07428096
- PF2020-CELL (UC-MSCs) - Allogeneic Human Umbilical Cord Mesenchymal Stem CellsPhase 1 · NCT05039411
- Platinum CompoundPhase 1 · NCT03816345
- Platinum DoubletPhase 1 · NCT03816345
- R-3750Phase 1 · NCT07791888
- SHR-7590Phase 1 · NCT07758101
- XylitolPhase 1 · NCT05852587
- CoQ10Early phase 1 · NCT06419335
- Non-invasive vagus nerve stimulation (nVNS)Early phase 1 · NCT07636304
- RD06-05 CART Cell InfusionEarly phase 1 · NCT07309744
- RosuvastatinEarly phase 1 · NCT06538649
Closest to patients
- Use of Crohn's Disease Exclusion Diet on Top of Standard Therapy Versus Standard Therapy Alone in Unstable Pediatric Crohn's Disease Patients.Phase 3 trial: Crohn's diseaseHôpital Femme mère enfant, CHU Lyon - Service Hépato-gastroentérologie et Nutrition pédiatrique · Bron, France + 3 more hospitalsPhase 3Results expected 2026
- Phase 3 Study of Human TH-SC01 Cell Injection for Treating Perianal Fistulas in Patients With Crohn's DiseasePhase 3 trial: Crohn's diseaseJiangsu Topcel-KH Pharmaceutical Co., Ltd. (sponsor) · 1 hospital in ChinaPhase 3Results expected 2026
- Ustekinumab and Upadacitinib for Induction and Maintenance Therapy in Patients With Refractory Crohn's Disease: A Multicenter, Randomized, Parallel-Controlled StudyPhase 3 trial: Ustekinumab (approximately 6 mg/kg), UpadacitinibSixth Affiliated Hospital, Sun Yat-sen University (sponsor)Phase 3Results expected 2026
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Results, new trials and publications, newest first. Every item links to its source.
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Socioeconomic status and long-term risk of inflammatory bowel disease: a prospective cohort study with mediation analysis.
Socioeconomic status and long-term risk of inflammatory bowel disease: a prospective cohort study with mediation analysis.
Journal of global health
PubMed · PMID 42990088Publication
E3 ubiquitin ligase WWP1 aggravates intestinal inflammation in CD‑like colitis: insights into KLF5 ubiquitination‑mediated NF‑κB signaling regulation.
E3 ubiquitin ligase WWP1 aggravates intestinal inflammation in CD‑like colitis: insights into KLF5 ubiquitination‑mediated NF‑κB signaling regulation.
Journal of molecular histology
PubMed · PMID 42993374Publication
Methodological considerations regarding tissue anti-tumour necrosis factor penetration in perianal Crohn's disease.
Methodological considerations regarding tissue anti-tumour necrosis factor penetration in perianal Crohn's disease.
European journal of gastroenterology & hepatology
PubMed · PMID 42992482Review
Outcome measurement in perianal Crohn's disease.
Outcome measurement in perianal Crohn's disease.
Techniques in coloproctology
PubMed · PMID 42993363
Organisations that can help
Helplines, patient groups and support services for you and your family.
Select your country to see the organisations there, starting with the ones closest to you.
Umbrella organisations (they connect national groups)
International Federation of Crohn's & Ulcerative Colitis Associations (formerly EFCCA)
Federation of national Crohn's and colitis patient associations: patient education (IFCCA Academy), reports, research involvement, World IBD Day and advocacy.
Visit site: International Federation of Crohn's & Ulcerative Colitis Associations (formerly EFCCA)
General support
For anyone who is ill, whatever the disease: patients' rights and legal aid, crisis lines, hospice and palliative care, care in another EU country, and patient organisations' umbrella bodies.
International
European Patients' Forum (EPF)
Umbrella of European patient organisations and national patient coalitions.
Visit site: European Patients' Forum (EPF)
International Alliance of Patients' Organizations
Global alliance of patient organisations of all diseases, promoting patient-centred healthcare.
Visit site: International Alliance of Patients' Organizations
Frontlight is not affiliated with these organisations; we list them because they help.
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Find fellow researchers
Groups with active Crohn's disease work.
Inserm
Paris, France
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Amsterdam University Medical Centers
Amsterdam, Netherlands
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University of Calgary
Calgary, Canada
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IRCCS Ospedale San Raffaele
Milan, Italy
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Western University
London, Canada
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Cleveland Clinic
Cleveland, United States
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Harvard University
Cambridge, United States
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Zhejiang University
Hangzhou, China
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Tel Aviv University
Tel Aviv, Israel
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Universitair Ziekenhuis Leuven
Leuven, Belgium
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Mayo Clinic
Rochester, United States
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