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Down syndrome

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Where research stands todayUpdated 13 Nov 2026
Trial-stage treatments you can join–open now
in United States
Studies published in the last 12 months00 in people · 0 in animals · 0 in the lab
Support organisations2organisations
in United States1 helpline
Offer tissue or dataGive a sample or your health data to research.Treatments outside United StatesWhere it is offered, and who pays.“Miracle cure” fact checkerSaw a cure online? Check it before you pay.

Trial-stage treatments and research studies you can join

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Get notified of new trialsUnited States, all cities, all phases
Your ageShows only trials that take people your age.
Phase
  1. Trial-stage treatmentPhase 2Taking people
    Tests blinatumomab with or without nivolumab in relapsed B-cell acute lymphoblastic leukemia

    Tests nivolumab added to blinatumomab in people with returned B-cell acute lymphoblastic leukemia.

    Akron, United StatesAlso Albany, Albuquerque, Allentown, Anaheim, Anchorage, Ann Arbor, Arroyo Grande, Asheville, …Age 1 to 30
  2. Trial-stage treatmentPhase 2Taking people
    Abrocitinib for Eczema and Patchy Hair Loss in People With Down Syndrome

    Tests abrocitinib for atopic dermatitis or alopecia areata in people with Down syndrome.

    New York, United StatesAge 12+
  3. Trial-stage treatmentPhase 2Taking people
    Mivelsiran Tested in Early Down Syndrome-Associated Alzheimer's Disease

    Tests mivelsiran against placebo in adults with early Down syndrome-associated Alzheimer's disease.

    Indianapolis, United StatesAlso Maitland, Naples, St LouisAge 40 to 55
  4. Trial-stage treatmentPhase 1Soon in United States
    Testing Higher Doses of Memantine in Young Adults With Down Syndrome

    Tests memantine at several doses for safety in adults with Down syndrome.

    Cleveland, United StatesAge 18 to 32
  5. Trial-stage treatmentPhase 2Taking people
    Phase 2 trial: Oxygen
    Ann Arbor, United StatesAlso Cincinnati, Cleveland, Los Angeles, Norfolk, Philadelphia, SeattleAge 5 to 18
  6. Trial-stage treatmentPhase 2Soon in United States
    Phase 2 trial: Ublituximab
    Los Angeles, United StatesAge 18 to 40
  7. Trial-stage treatmentPhase 4Taking people
    Phase 4 trial: ato-oxy, Oxygen
    Miami, United StatesAlso Park Ridge, Philadelphia, San Diego, TucsonAge 6+
  8. Trial-stage treatmentPhase 2Taking people
    Phase 2 trial: Tofacitinib Oral Solution
    Aurora, United StatesAge 6 to 22
  9. Trial-stage treatmentTaking people
    Clinical trial: Self-Supporting Nasopharyngeal Airway (ssNPA)
    Ann Arbor, United StatesAge 3 to 21
  10. Trial-stage treatmentPhase 1Soon in United States
    Testing MIB-626 for safety in adults with Down syndrome to address Alzheimer's disease

    Tests the safety of MIB-626 tablets in adults with Down syndrome.

    Boston, United StatesAge 18+
  11. Trial-stage treatmentPhase 2Taking people
    Phase 2 trial: Metric-optimized spectacles, Routine Clinical Spectacles
    Columbus, United StatesAge 5 to 12
  12. Trial-stage treatmentPhase 1/2Taking people
    Tests ACI-24.060 in early Alzheimer's disease and adults with Down syndrome

    Tests ACI-24.060 safety in early Alzheimer's and in adults with Down syndrome.

    Boston, United StatesAlso Cordova, Fairway, Indianapolis, Lady Lake, Matthews, Nashville, Orlando, Phoenix, …Age 35 to 85
  13. Trial-stage treatmentTaking people
    Testing light and sound brain stimulation in adults with Down syndrome

    Tests light and sound brain stimulation in adults with Down syndrome.

    Cambridge, United StatesAge 25 to 65
  14. Trial-stage treatmentPhase 3Taking people
    Phase 3 trial: Epi-ON corneal cross-linking (CXL)
    Asheville, United StatesAlso Atlanta, Canton, Chattanooga, Cumming, Douglasville, Johnson City, Knoxville, Lawrenceville, …Age 8+
  15. Trial-stage treatmentTaking people
    Clinical trial: Portable oxygen concentrator Inogen G5 model
    Cincinnati, United StatesAge 5 to 17
  16. Trial-stage treatmentPhase 1
    Phase 1 trial: Methylphenidate Oral Solution
    Chicago, United StatesAlso Cincinnati, SacramentoAge 6 to 24
  17. Trial-stage treatment
    Clinical trial: Self-Supporting Nasopharyngeal Airway (ssNPA)
    Ann Arbor, United StatesAge 3 to 23
  18. Trial-stage treatmentTaking people
    Clinical trial: Hypoglossal Nerve Stimulation
    Cleveland, United StatesAlso Houston, Orange, Phoenix, Queens, TampaAge 13 to 18
  19. Trial-stage treatmentTaking people
    Clinical trial: Down Syndrome
    Boston, United StatesUp to age 2
  20. Trial-stage treatmentSoon in United States
    Clinical trial: Down Syndrome
    Fort Collins, United StatesAge 3 to 6

Support organisations

Patient organisations and helplines in United States, for you and your family.

We have no organisations for this disease listed in United States yet. General support there is below.

General support in United States

  • 988 Suicide & Crisis Lifeline

    US national 24/7 free and confidential lifeline for anyone in suicidal crisis or emotional distress, reachable by calling or texting 988 or by chat.

    988lifeline.org
  • MedlinePlus

    Free, easy-to-read health information service of the US National Library of Medicine (NIH) on diseases, conditions, drugs and wellness.

    medlineplus.gov

International organisations

Patient organisation umbrella bodies

Offer tissue or data

There are three ways to help research move faster.

Give tissue or bloodA biobank stores your sample so many research teams can use it.No open programme yet
Share your health dataA patient registry collects your health data, without your name, for research.How to join
Take part as a healthy volunteerStudies also need people without the disease, for comparison. Family and friends can help.Volunteer

“Miracle cure” fact checker

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Before you pay for anything, ask three things

  1. Is there a published study in people?
  2. Can I have the full price in writing?
  3. What does my doctor say?

“Cures” others already fact-checked

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