University of California, San Francisco
San Francisco, United States
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Frontotemporal dementia
What is new in Frontotemporal dementia research, which clinical trials are open, and who works on it. From public registries and PubMed, with the source and date of every fact.
Cure status
- N-Acetyl-L-LeucinePhase 3 · NCT05163288
- AZ-3102Phase 2/3 · NCT07885917
- Active tDCS + Language TherapyPhase 2 · NCT05386394
- Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine)Phase 2 · NCT05331144
- Lemborexant 10 MGPhase 2 · NCT06823752
- MetforminPhase 2 · NCT04220021
- NeflamapimodPhase 2 · NCT07033481
- NIO752Phase 2 · NCT07868328
- NS101 IV infusionPhase 2 · NCT07154485
- VortioxetinePhase 2 · NCT06604520
- DNL593Phase 1/2 · NCT05262023
- Intrathalamic AVB-101Phase 1/2 · NCT06064890
- LY3884963Phase 1/2 · NCT04408625
- MethylprednisolonePhase 1/2 · NCT04408625
- Optional PrednisonePhase 1/2 · NCT04408625
- Optional SirolimusPhase 1/2 · NCT04408625
- Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes （High-Dose）Phase 1/2 · NCT07638813
- Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes （Low-Dose）Phase 1/2 · NCT07638813
- DUOC-01Phase 1 · NCT02254863
- ET-STEMPhase 1 · NCT05315661
- LY3954068Phase 1 · NCT06297590
- VerdiperstatPhase 1 · NCT05184569
- PropranololEarly phase 1 · NCT06066710
Closest to patients
- PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620Phase 3 trial: Frontotemporal dementiaPerelman Center for Advance Medicine · Philadelphia, United StatesPhase 3Results expected 2028
- Long-Term Safety and Tolerability of Nizubaglustat in Participants With Rare Lysosomal DisordersPhase 2/3 trial: AZ-3102Azafaros B.V. (sponsor)Phase 2/3Results expected 2030
- A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type CPhase 3 trial: N-Acetyl-L-LeucineRoyal Manchester Children's Hospital · Manchester, United Kingdom + 13 more hospitalsPhase 3Results expected 2030
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Latest news
Results, new trials and publications, newest first. Every item links to its source.
Results and new studies, newest first, in plain words.
Plain-language summary pending. Original title shown.
Publication
Financial mismanagement leading to genetic diagnosis of familial frontotemporal dementia.
Financial mismanagement leading to genetic diagnosis of familial frontotemporal dementia.
Journal of the Formosan Medical Association = Taiwan yi zhi
PubMed · PMID 42982692Publication
Causal inference analysis of the effect of amyloid-β and tau proteins on dementia risk: A Mendelian randomization analysis.
Causal inference analysis of the effect of amyloid-β and tau proteins on dementia risk: A Mendelian randomization analysis.
Journal of Alzheimer's disease : JAD
PubMed · PMID 42979808Meta-analysis
The shared genetic architecture of the TDP-43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes.
The shared genetic architecture of the TDP-43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes.
Alzheimer's & dementia : the journal of the Alzheimer's Association
PubMed · PMID 42982761Publication
Frontal Cerebral Blood Flow Deficits in Behavioral Variant Frontotemporal Dementia: Associations With Clinical Symptoms, Peripheral Vascular Biomarkers, and Neuroimaging Measures.
Frontal Cerebral Blood Flow Deficits in Behavioral Variant Frontotemporal Dementia: Associations With Clinical Symptoms, Peripheral Vascular Biomarkers, and Neuroimaging Measures.
CNS neuroscience & therapeutics
PubMed · PMID 42968588Publication
Predictors of 6-month clinical change in primary progressive aphasia following language therapy and transcranial magnetic stimulation.
Predictors of 6-month clinical change in primary progressive aphasia following language therapy and transcranial magnetic stimulation.
Brain communications
PubMed · PMID 42973818
Organisations that can help
Helplines, patient groups and support services for you and your family.
Select your country to see the organisations there, starting with the ones closest to you.
Umbrella organisations (they connect national groups)
Alzheimer Europe
Umbrella of national Alzheimer associations in 39 countries, with a member directory.
Visit site: Alzheimer Europe
Alzheimer's Disease International (ADI)
Global federation of dementia associations in 100+ countries: member associations list, find local support, dementia information, World Alzheimer Report.
Visit site: Alzheimer's Disease International (ADI)
General support
For anyone who is ill, whatever the disease: patients' rights and legal aid, crisis lines, hospice and palliative care, care in another EU country, and patient organisations' umbrella bodies.
International
European Patients' Forum (EPF)
Umbrella of European patient organisations and national patient coalitions.
Visit site: European Patients' Forum (EPF)
International Alliance of Patients' Organizations
Global alliance of patient organisations of all diseases, promoting patient-centred healthcare.
Visit site: International Alliance of Patients' Organizations
Frontlight is not affiliated with these organisations; we list them because they help.
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Find fellow researchers
Groups with active Frontotemporal dementia work.
University College London
London, United Kingdom
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UCL Queen Square Institute of Neurology
London, United Kingdom
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Mayo Clinic
Rochester, United States
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Harvard University
Cambridge, United States
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University of Cambridge
Cambridge, United Kingdom
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McGill University
Montreal, Canada
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University of Toronto
Toronto, Canada
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University of Milan
Milan, Italy
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Inserm
Paris, France
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The University of Sydney
Sydney, Australia
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UK Dementia Research Institute
London, United Kingdom
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