Age and Procedural Timing for Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial.

What was studied

This study looked again at the EARLY TAVR trial, by age. That trial compared early valve replacement with watchful follow-up. People had severe aortic stenosis and no symptoms. They were split into 4 age groups. These ran from 65 to 69 years up to 80 years or older. The study asked if the effect of early replacement differed by age.

What they found

No link between age and the effect of early replacement was found. Stroke rates were lower with early replacement at ages 65 to 69. They were also lower at ages 80 or older. At 2 years, heart failure hospital stays fell most in the oldest group. In the follow-up group, time to later replacement was alike across ages. The median was 11 months.

What it means for patients

The authors say early replacement helped in a similar way at all ages. They say the data point to early replacement as an option above 65 years.

Why it is not certain yet

This was a look at age groups within one trial. Each group was small, from 141 to 263 people. A rise in acute valve syndrome with age was not clear-cut. Its P value was 0.06.

Source

Age and Procedural Timing for Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial.

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