Oral Clues to Undiagnosed Congenital Hemophilia: A Systematic Review of Case Reports.

What was studied

This review looked at oral signs of hemophilia that had not been diagnosed. It covered case reports and case series in English. The team searched MEDLINE, Scopus, CINAHL, ProQuest and EMBASE up to August 2025. They found 282 articles. They kept reports on dental treatment in hemophilia A or B. They left out acquired hemophilia and inhibitor-positive cases.

What they found

Some reports described a first sign of undiagnosed hemophilia. It was long bleeding in the mouth after tooth removal. This included 6 case reports and a case series. Bleeding that began late after dental treatment was a warning sign. It began from Day 2. The authors say it should raise suspicion of hemophilia A or B.

What it means for patients

The authors say mild hemophilia is often overlooked. They say its signs are easy to neglect. They say dental professionals are at the front line of diagnosis. They say bleeding that starts late should raise suspicion.

Why it is not certain yet

The review covers case reports and one case series. These are weak designs for firm conclusions. The abstract does not give a count of patients. Cases of acquired hemophilia were left out.

Source

Oral Clues to Undiagnosed Congenital Hemophilia: A Systematic Review of Case Reports.

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