A Systematic Review and Meta-Analysis of Glyphosate-Based Herbicide Exposure and Risk of Non-Hodgkin Lymphoma.

What was studied

This systematic review and meta-analysis studied glyphosate-based herbicides. It asked about the risk of non-Hodgkin lymphoma (NHL). These are widely used farm chemicals. Concerns about cancer risk persist. The authors searched MEDLINE and EMBASE. They included cohort, case-control and pooled studies. They rated bias and graded certainty with GRADE. They also ran sensitivity analyses to test the findings.

What they found

Ever-exposure went with an odds ratio of 1.11. This link was modest. Analyses of the highest exposure showed a significant link with NHL. Higher glyphosate exposure was consistently tied to more NHL risk. The findings held across sensitivity analyses. The tests checked for overlap between cohorts and for how hazard ratios were included. They also checked exposure definitions and model overfitting.

What it means for patients

The authors say links for ever-exposure were modest. They say higher exposure was consistently linked to more NHL. They say the findings were robust across sensitivity analyses.

Why it is not certain yet

These were observational studies, so links do not prove cause. The abstract gives no risk estimate for the highest exposure. It does not give the GRADE ratings. The abstract does not list how many people took part.

Source

A Systematic Review and Meta-Analysis of Glyphosate-Based Herbicide Exposure and Risk of Non-Hodgkin Lymphoma.

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