Cardiac Damage and Clinical Outcomes in Symptomatic Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

What was studied

This was a later analysis of the LANDMARK trial. The trial had 768 people with severe aortic stenosis. They had a new valve placed through a catheter. Heart damage was sorted into stages 0 to 4. Stage 0 meant none, and stage 4 meant right ventricle damage. The main outcome was death within 1 year.

What they found

Stages were assessed in 596 people. Death within 1 year rose with each stage of damage. People with damage at all stages had the highest death rate. Stage 4 was linked to higher 1-year death even after adjustment. The mean age was 80.2 years.

What it means for patients

The authors say the updated staging sorted death risk at 1 year after valve replacement. They say a full heart ultrasound exam has value in severe aortic stenosis.

Why it is not certain yet

This was a later analysis, not planned in advance. Stages were assessed in 596 of the 768 people. The abstract gives no results beyond 1 year. Links to death are not proof of cause.

Source

Cardiac Damage and Clinical Outcomes in Symptomatic Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

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