Diagnostic value of urinary exosomes in patients with IgA nephropathy and diabetic kidney disease: a systematic review and meta-analysis.

What was studied

This review looked at urinary exosomes, a new kind of marker found in urine. The team asked if they can help spot kidney illness. They looked at kidney disease from diabetes, called DKD. They also looked at IgA nephropathy, called IgAN. They searched medical databases for past studies up to December 2025. They then pooled data from 22 papers with 6,482 people in total.

What they found

For DKD, the urine test did well. One score shows how well a test tells sick from not sick. A higher score means a better test. For DKD, this score was 0.91. For IgAN, the same score was 0.81. The test also caught sick people more often in DKD than in IgAN. Its specificity was also higher for DKD than for IgAN.

What it means for patients

The authors say the test worked better for DKD than for IgAN. For IgAN, they see only a moderate role for the test. They say its place in daily care for IgAN is not clear yet. They do not say the test is ready for routine use in either illness.

Why it is not certain yet

The authors say more work is needed before routine use. New studies should follow people forward in time. They should use the same fixed methods. They should set the cut-off for a positive test in advance. The abstract does not say how well the pooled studies were done. A review can only be as good as the studies in it.

Source

Diagnostic value of urinary exosomes in patients with IgA nephropathy and diabetic kidney disease: a systematic review and meta-analysis.

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