Glycemic dysregulation and insulin resistance across acute and post-acute COVID-19: a systematic review and meta-analysis of etiologic and prognostic evidence.

What was studied

This review looked at blood sugar problems and insulin resistance. It covered the acute and later stages of COVID-19. It used 23 reports. It asked if acute high blood sugar types went with worse outcomes. Other evidence was summarized in words.

What they found

Acute high blood sugar types were linked to higher short-term death. This was seen in 1,079 people. They were also linked to more invasive mechanical ventilation, in 679 people. Adding a large study kept the death link but made ventilation results vary. After COVID-19 there was no single path. Problems cleared in some groups and lasted in others.

What it means for patients

The team says acute high blood sugar types went with worse COVID-19 outcomes. They stress that these numbers should not be read as causal. They call for shared definitions and long studies that follow people.

Why it is not certain yet

The risk estimates were unadjusted. The plan for the review was registered on 21 August 2026, after the work began. Lasting problems occurred unevenly across studies. Some results depended on which large study was added.

Source

Glycemic dysregulation and insulin resistance across acute and post-acute COVID-19: a systematic review and meta-analysis of etiologic and prognostic evidence.

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