Rehabilitative efficacy of cognitive behavioral therapy-based intervention for chronic fatigue syndrome: A systematic review and meta-analysis.

What was studied

This meta-analysis looked at cognitive behavioral therapy for chronic fatigue syndrome. Earlier studies were inconsistent. Their long-term results varied. Databases searched were Embase, PubMed, Web of Science and Cochrane. The search ran to March 2025. Randomized trials in diagnosed people were included. It was given face-to-face, in groups or online. The review pooled the trials. The main outcome was the fatigue score. Others were physical function, mood and adverse events. The aim was to see if the therapy helps. The trials had 2270 participants.

What they found

Therapy led to clear gains after treatment. Fatigue scores fell on the rating scales used. Physical function rose. Mood improved, with less anxiety and depression. Fatigue relief and better function held at short-term follow-up. They also held from 6 to 24 months. Adverse event rates did not differ.

What it means for patients

The authors say the therapy may be an effective option for this syndrome. They say more research is warranted.

Why it is not certain yet

The authors say more research is needed. Subgroup checks probed the spread between studies. The abstract names no other limits.

Source

Rehabilitative efficacy of cognitive behavioral therapy-based intervention for chronic fatigue syndrome: A systematic review and meta-analysis.

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