Physiological prehabilitation for patients undergoing cellular therapy in multiple myeloma and lymphoma: a systematic review.

What was studied

This review looked at exercise before cell therapy. The people had myeloma or lymphoma. The therapies were stem cell transplant, CAR-T and BiTE therapy. The team searched databases up to 4 September 2026. The review included 501 people in total. The studies were summed up in words.

What they found

Exercise was mostly aerobic work mixed with strength work. Physical function results were generally favourable. So were leg performance results. Handgrip strength, quality of life and fatigue results were mixed. No study looked at BiTE therapy.

What it means for patients

The authors say exercise before treatment shows early signs of help. This is for getting the body ready. They say aerobic and resistance exercise needs comparison tests. So do the common program lengths.

Why it is not certain yet

Methods differed across the studies. Many designs had no control group. Only a few were randomised pilot trials. The authors say larger trials are needed. They should check safety and lasting recovery. A review can only be as good as the studies in it.

Source

Physiological prehabilitation for patients undergoing cellular therapy in multiple myeloma and lymphoma: a systematic review.

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