The role of microRNAs in neuroblastoma cell differentiation and their therapeutic potential: a systematic review.

What was studied

This review looked at microRNAs that push neuroblastoma cells to mature. Neuroblastoma is a common solid tumor outside the brain in young children. The aim was to map which microRNAs matter. High-risk disease has low survival. Retinoic acid helps tumor cells mature, but relapse stays high. The team searched Ovid MEDLINE and Embase up to June 2023. 396 articles were screened. 89 met the criteria.

What they found

53 entries of single microRNAs and groups had a role in differentiation. miR-124, miR-34 and miR-506-3p are well studied. They strongly stimulated differentiation. Loss of these was linked with lower patient survival. The miR-17-92 cluster worked against differentiation. It was linked with poor survival. The review listed their roles in differentiation.

What it means for patients

The authors say data suggest miR-124, miR-34 and miR-506-3p may promote tumor cell maturation. They add that large barriers remain before clinical use.

Why it is not certain yet

Much of the evidence is preclinical. Large translational barriers remain before clinical use. Only English articles were included. The search ran up to June 2023.

Source

The role of microRNAs in neuroblastoma cell differentiation and their therapeutic potential: a systematic review.

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