Capital Medical University
Beijing, China
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Neuromyelitis optica (NMOSD)
What is new in Neuromyelitis optica (NMOSD) research, which clinical trials are open, and who works on it. From public registries and PubMed, with the source and date of every fact.
Cure status
- eculizumabPhase 3 · NCT06724809
- Rapid-tapering glucocorticoids + InebilizumabPhase 3 · NCT07132398
- RavulizumabPhase 3 · NCT05346354 · NCT07557420
- SatralizumabPhase 3 · NCT05199688
- Slow-tapering glucocorticoids + InebilizumabPhase 3 · NCT07132398
- InebilizumabPhase 2 · NCT05549258
- OfatumumabPhase 1/2 · NCT05504694
- CC-97540 (BMS-986353)Phase 1 · NCT07573332
- CE211NS21Phase 1 · NCT07595965
- CyclophosphamidePhase 1 · NCT07573332
- FludarabinePhase 1 · NCT07573332
- TocilizumabPhase 1 · NCT07573332
Closest to patients
- A Study to Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, and Pharmacodynamics of Satralizumab in Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)Phase 3 trial: SatralizumabInstytut Pomnik Centrum Zdrowia Dziecka · Warsaw, Poland + 12 more hospitalsPhase 3Results expected 2027
- Slow vs. Rapid Glucocorticoids Tapering With Inebilizumab in NMOSDPhase 3 trial: Slow-tapering glucocorticoids + Inebilizumab, Rapid-tapering glucocorticoids + InebilizumabTianjin Medical University General Hospital (sponsor)Phase 3Results expected 2027
- Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity Study of Ravulizumab in Chinese Adults With Neuromyelitis Optica Spectrum Disorder (NMOSD)Phase 3 trial: RavulizumabAlexion Pharmaceuticals, Inc. (sponsor) · 9 hospitals in ChinaPhase 3Results expected 2028
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Latest news
Results, new trials and publications, newest first. Every item links to its source.
Results and new studies, newest first, in plain words.
Plain-language summary pending. Original title shown.
Review
Role of microglia in neuromyelitis optica (Review).
Role of microglia in neuromyelitis optica (Review).
International journal of molecular medicine
PubMed · PMID 42992581Publication
A Case Report of Early Multimodal Immunotherapy for Rapidly Progressive Neuromyelitis Optica Spectrum Disorder with Extensive Brain Lesions.
A Case Report of Early Multimodal Immunotherapy for Rapidly Progressive Neuromyelitis Optica Spectrum Disorder with Extensive Brain Lesions.
Internal medicine (Tokyo, Japan)
PubMed · PMID 42983799Publication
Phenotypic and immunological profile divergence between SLE-associated myelitis and SLE-NMOSD overlap syndrome: a retrospective case series.
Phenotypic and immunological profile divergence between SLE-associated myelitis and SLE-NMOSD overlap syndrome: a retrospective case series.
Frontiers in immunology
PubMed · PMID 42978709Publication
Association between psychosocial consequences of visual dysfunction and depressive symptom burden in multiple sclerosis and neuromyelitis optica spectrum disorder.
Association between psychosocial consequences of visual dysfunction and depressive symptom burden in multiple sclerosis and neuromyelitis optica spectrum disorder.
Frontiers in neurology
PubMed · PMID 42978592Publication
AQP4 antibody-induced astrocyte injury reshapes CNS immune architecture in a combined EAE-AQP4-IgG model of neuromyelitis optica spectrum disorder.
AQP4 antibody-induced astrocyte injury reshapes CNS immune architecture in a combined EAE-AQP4-IgG model of neuromyelitis optica spectrum disorder.
Frontiers in immunology
PubMed · PMID 42973689
Organisations that can help
Helplines, patient groups and support services for you and your family.
Select your country to see the organisations there, starting with the ones closest to you.
Umbrella organisations (they connect national groups)
EURORDIS – Rare Diseases Europe
Alliance of over 1,000 rare disease patient organisations, with a list of rare disease helplines by country.
Visit site: EURORDIS – Rare Diseases EuropeThe Guthy-Jackson Charitable Foundation
NMOSD foundation (US-based, international reach): newly-diagnosed guides, patient resource guide, NMO Patient Days, directory of advocacy groups, expert-clinician map, research.
Visit site: The Guthy-Jackson Charitable Foundation
The Sumaira Foundation for NMO
NMOSD and MOGAD patient foundation (US-based): support groups, caregiver conversations, patient days, education brochures, webinars, assistance programmes.
Visit site: The Sumaira Foundation for NMO
General support
For anyone who is ill, whatever the disease: patients' rights and legal aid, crisis lines, hospice and palliative care, care in another EU country, and patient organisations' umbrella bodies.
International
European Patients' Forum (EPF)
Umbrella of European patient organisations and national patient coalitions.
Visit site: European Patients' Forum (EPF)
International Alliance of Patients' Organizations
Global alliance of patient organisations of all diseases, promoting patient-centred healthcare.
Visit site: International Alliance of Patients' Organizations
Frontlight is not affiliated with these organisations; we list them because they help.
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Find fellow researchers
Groups with active Neuromyelitis optica (NMOSD) work.
Charité – Universitätsmedizin Berlin
Berlin, Germany
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Mayo Clinic
Rochester, United States
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Harvard University
Cambridge, United States
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Massachusetts General Hospital
Boston, United States
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Humboldt-Universität zu Berlin
Berlin, Germany
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Max Delbrück Center
Berlin, Germany
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Beijing Tian Tan Hospital
Beijing, China
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Isfahan University of Medical Sciences
Isfahan, Iran
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Tianjin Medical University General Hospital
Tianjin, China
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University of Oxford
Oxford, United Kingdom
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Johns Hopkins University
Baltimore, United States
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