Association of rs3736228 polymorphism in LRP5 gene with bone fracture and osteoporosis: a systematic review and updated meta-analysis.

What was studied

This was a review and updated meta-analysis. It looked at a gene variant, rs3736228, in the LRP5 gene. LRP5 helps control bone density. The authors asked if the variant links to osteoporosis and fractures. They also looked at groups by sex, menopause and ethnicity. They searched several databases and checked reference lists. They included 14 studies, with 16 comparisons. They had 1,549 patients and 3,345 controls.

What they found

The variant was linked to a higher risk of osteoporosis and fractures. This held in several gene models. In the allelic model, the odds ratio was 1.17. Males showed higher risk in some models. Females showed higher risk in other models. With controls from the general public, links showed in several models. These were the allelic, homozygous, dominant and recessive models. With hospital-based controls, no clear link was found. Disease type, year and control source explained part of the differences between studies.

What it means for patients

The authors say the variant is linked to osteoporosis and fracture risk. This fits large gene studies. They say links look weaker in males and in women before menopause.

Why it is not certain yet

Subgroup results came from small samples. The authors say to read them with care. Differences between studies were only partly explained. The authors call for large, forward-looking studies. These should check whether the results help sort people by risk in care.

Source

Association of rs3736228 polymorphism in LRP5 gene with bone fracture and osteoporosis: a systematic review and updated meta-analysis.

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