Prolonged exposure, eye movement desensitization and reprocessing therapy, and cognitive restructuring versus waiting-list for individuals with PTSD and psychosis (RE.PROCESS): A multicenter, four-arm, assessor-masked, superiority randomized controlled trial.

What was studied

This trial tested trauma therapies in adults with PTSD and a psychosis disorder. The therapies were prolonged exposure, EMDR and cognitive restructuring. All were given with usual care. A waiting-list group also got usual care. In all, 162 people were split at random. Therapy had up to 16 sessions. People were followed to 6 months.

What they found

Each therapy reduced PTSD severity more than waiting did. The gap on the CAPS-5 scale at 6 months was -9.76 for prolonged exposure. It was -11.74 for EMDR and -12.72 for cognitive restructuring. The effects were large. Psychosis symptoms did not change significantly.

What it means for patients

The authors say the therapies reduced PTSD symptoms in people with psychosis, with large effects. They say the results support wider access to trauma therapy for this underserved group.

Why it is not certain yet

The authors say larger samples are needed to repeat these results. Follow-up was only 6 months. The abstract does not compare the therapies with each other. It gives no results beyond 6 months.

Source

Prolonged exposure, eye movement desensitization and reprocessing therapy, and cognitive restructuring versus waiting-list for individuals with PTSD and psychosis (RE.PROCESS): A multicenter, four-arm, assessor-masked, superiority randomized controlled trial.

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