Deficient Monetary Reward Processing in Schizophrenia: A Meta-Analysis and Computational Modeling of a Monetary Incentive Delay Task.

What was studied

This study looked at reward processing in schizophrenia (SZ). Evidence on the Monetary Incentive Delay (MID) task in SZ was mixed. The team joined a meta-analysis of MID studies with a new MID study. It used 30 studies, with 785 people with SZ and 755 healthy controls (HCs). The new study had 60 people with SZ and 74 HCs. A learning model (Rescorla-Wagner) gave prediction-error (PE) and expected-value (Q) indices.

What they found

The meta-analysis showed small-to-moderate differences in SZ. People with SZ had longer reaction times and lower correct rates on reward trials. In the new study, they also had longer reaction times. They had lower correct rates on reward and loss trials, and higher on neutral trials. The model showed higher prediction errors and lower reward expected value in SZ. Loss-related indices were linked to negative symptom scores.

What it means for patients

The authors said SZ is linked to altered MID task performance. They said it is also linked to altered model-derived PE and Q indices. They said these indices may help describe incentive-processing problems in SZ.

Why it is not certain yet

The clinical and neurobiological meaning of these indices needs validation. The authors call for longitudinal and multimodal studies. Results rest on one model, the Rescorla-Wagner framework.

Source

Deficient Monetary Reward Processing in Schizophrenia: A Meta-Analysis and Computational Modeling of a Monetary Incentive Delay Task.

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