Target

AMPK

AMP-activated protein kinase

9open trials
13trials in total
1057publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
Effect of Weight Management on AMPK Activation in the Adjunctive Treatment of Endometrial Cancer
1 Jan 2027· NA · NOT_YET_RECRUITING· CTGOV
Publication
Evodiamine inhibits lung cancer by rectifying abnormal glycolysis via the AMPK signaling pathway.
4 Nov 2026· European journal of pharmacology· PUBMED
Publication
YAP coordinates lipid and cholesterol metabolism in papillary thyroid cancer through a glucose-AMPK-gated TEAD1-SREBP1/2 axis.
4 Nov 2026· Endocrine-related cancer· PUBMED
Publication
Chongcao Qingfei Capsule alleviates house dust mite-induced allergic airway inflammation by regulating metabolic homeostasis via modulation of the PDE7A-cAMP-AMPK-mTOR axis.
4 Nov 2026· Journal of ethnopharmacology· PUBMED
Publication
Tembusu virus induces lipid droplet accumulation to facilitate viral replication in neuronal cells via AMPK-mediated ATGL suppression.
4 Nov 2026· Veterinary research· PUBMED
Publication
The AMPK-ALDH7A1 axis drives metabolic reprogramming and anti-tumor immunity in hepatocellular carcinoma via KDM5C inhibition.
3 Nov 2026· Developmental cell· PUBMED
Publication
Myeloid-Derived Growth Factor Alleviates Diabetic Non-Alcoholic Fatty Liver Disease by Up-Regulating ABCA1 and ABCG1 Expression via the AMPK/PPARγ/LXRα Pathway.
1 Nov 2026· Journal of cellular and molecular medicine· PUBMED
Publication
Calycosin Promotes Ferroptosis in Cervical Cancer via the AMPK/PI3K-TFEB-Autophagy-Lysosome Axis.
1 Nov 2026· Journal of cellular biochemistry· PUBMED
Publication
Remote ischemic preconditioning protects against cerebral ischemia/reperfusion injury through lactate-dependent AMPK/ULK1 signaling and autophagy.
30 Oct 2026· Experimental neurology· PUBMED
Publication
Zederone-calycosin ameliorates psoriasis via the AMPK/SIRT1/PGC-1α pathway: insights from the Astragali Radix-Curcumae Rhizoma herb pair.
30 Oct 2026· International immunopharmacology· PUBMED
Publication
Dietary Polysaccharides for Overweight and Obesity Management: Targeting AMPK via the Gut Microbiota and Metabolites-A Review.
29 Oct 2026· Nutrition reviews· PUBMED
Publication
Magnoflorine Ameliorates MASH in Mice Fed a High-Fat and High-Fructose Diet by Promoting AMPK-Mediated Lipophagy and Fatty Acid Oxidation.
27 Oct 2026· Phytotherapy research : PTR· PUBMED
Publication
Exercise alleviates skeletal muscle dysfunction in COPD by regulating mitochondrial function via apelin/AMPK signaling.
26 Oct 2026· Histochemistry and cell biology· PUBMED
Publication
AMPK-dependent mechanisms mediate the protective effects of grape pomace extract in obesity-associated chronic renal disease in mice.
26 Oct 2026· Food & function· PUBMED
Publication
Thyroid-stimulating hormone exacerbates mitochondrial energy dysregulation and cardiac remodeling with involvement of the AMPK/PGC-1α pathway.
23 Oct 2026· Journal of endocrinological investigation· PUBMED
Publication
Licorice flavonoids ameliorate type 2 diabetes mellitus via modulation of the AMPK/mTORC1/AKT signaling network.
22 Oct 2026· Journal of drug targeting· PUBMED
Publication
A trifluoromethylated chalcone derivative attenuates Alzheimer disease-related Aβ/Tau pathology by modulating the AMPK-dependent autophagy-proteostasis axis.
21 Oct 2026· Pharmacological research· PUBMED
Publication
Magnoflorine Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Targeting the NDUFV1 Subunit of Complex I to Regulate the ROS/AMPK Signaling Pathway.
21 Oct 2026· Journal of agricultural and food chemistry· PUBMED
Publication
NUAK isoforms promote glucose and glutamine metabolic reprogramming driven colon cancer progression and migration through regulation of AMPK/mTOR signaling.
20 Oct 2026· Journal of molecular medicine (Berlin, Germany)· PUBMED
Publication
[Jiaotaiwan improves lipid metabolism abnormalities in a mouse model of Alzheimer disease by regulating the AMPK signaling pathway].
20 Oct 2026· Nan fang yi ke da xue xue bao = Journal of Southern Medical University· PUBMED
Publication
The potential impact of radiation-synthesized chitosan coated titanium dioxide nanoparticles on hepatocellular carcinoma: Modulation of autophagy via AMPK, mTOR, and ULK-1 pathways in a rat model.
20 Oct 2026· Bioorganic chemistry· PUBMED
Publication
Shikonin Promotes Apoptosis in Multiple Myeloma Cells Through the PKM2-AMPK-PGC1α Metabolic Axis.
20 Oct 2026· Journal of clinical laboratory analysis· PUBMED
Publication
Hyperglycemia-Induced Loss of Astrocytic Kir4.1 Is Associated with Increased DNMT1 Activity and Altered AMPK/SIRT1 Signaling.
20 Oct 2026· Cells· PUBMED
Publication
Correction: Sinigrin, a bioactive compound from cruciferous vegetables, ameliorates MASLD by activating AMPK/SIRT1/PGC-1α to enhance fatty acid beta-oxidation.
19 Oct 2026· Food & function· PUBMED
Publication
Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+-CaMKK2-AMPK Signaling to Counter MASLD.
18 Oct 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Caffeine and Exercise in Obesity-Associated Brain Aging and Neurodegeneration: Mechanistic Insights into AMPK/SIRT1/PGC-1α, BDNF/TrkB, and NLRP3 Inflammasome Signaling.
16 Oct 2026· Molecular neurobiology· PUBMED
Publication
Disporum cantoniense suppresses non‑small cell lung cancer through AMPK/mTOR/ULK1‑mediated autophagy‑dependent apoptosis.
16 Oct 2026· International journal of oncology· PUBMED
Publication
miR-615-3p targets SESN2 to inhibit neuronal mitophagy in an in vitro Alzheimer's disease model by regulating the AMPK/ULK1 axis.
16 Oct 2026· Frontiers in molecular neuroscience· PUBMED
Publication
Deubiquitinase OTUB1 attenuates pathological cardiac hypertrophy by activating the AMPK signaling pathway.
15 Oct 2026· Journal of cardiovascular pharmacology· PUBMED
Publication
Sodium Butyrate Ameliorates Hepatic Steatosis and Insulin Resistance in MASLD Models With Concurrent Alterations in AMPK and PI3K/AKT Signaling.
14 Oct 2026· Frontiers in bioscience (Landmark edition)· PUBMED

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