Target

NMDA

NMDA receptor

Also: NMDAR

19open trials
32trials in total
192publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
1 Dec 2026· PHASE2_PHASE3 · RECRUITING· CTGOV
Publication
The efficacy of NMDA receptor antagonists in neuropsychiatric and non-motor symptoms of Parkinson's disease: a systematic review.
2 Nov 2026· Dementia & neuropsychologia· PUBMED
Publication
Differential NMDA-Evoked Excitatory and Inhibitory Neuronal Responses Under In Vivo and Ex Vivo Conditions in 5xFAD Mice.
1 Nov 2026· The European journal of neuroscience· PUBMED
Publication
Discovery of potent, selective, and orally bioavailable GluN2B-NMDA receptor antagonists for the treatment of depression.
29 Oct 2026· European journal of medicinal chemistry· PUBMED
Publication
ASIC1a as an integrating node in ischemic neurotoxicity: crosstalk with NMDAR and TRPM signaling.
20 Oct 2026· Pflugers Archiv : European journal of physiology· PUBMED
Trial
Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases
1 Oct 2026· NA · NOT_YET_RECRUITING· CTGOV
Publication
Embryonic Depletion of D-Aspartate Perturbs NMDA Receptor-Dependent Long-Term Potentiation in the Hippocampus of Juvenile Mice.
1 Oct 2026· Journal of neurochemistry· PUBMED
Publication
Predictive value of persistent cerebrospinal fluid antibodies at 12 months for long-term clinical outcomes in pediatric anti-NMDAR encephalitis: a retrospective cohort study.
1 Oct 2026· Frontiers in immunology· PUBMED
Publication
Sex-Divergent Patterns in Hippocampal and Cortical NMDA Receptor Density Across the Alzheimer's Disease Continuum.
25 Sept 2026· International journal of molecular sciences· PUBMED
Publication
Thalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction.
23 Sept 2026· Science advances· PUBMED
Publication
A Cell Type-Specific Switch in GluN2D NMDA Receptors Drives Cortical Circuit Hyperexcitability and Sensory-Driven Cortical Synchronization Deficits in a Fragile X Syndrome Model.
21 Sept 2026· Biological psychiatry· PUBMED
Publication
Hippocampal LTP shifts from NMDAR dependence to mGluR/VGCC-supported mechanisms following juvenile status epilepticus in rats.
20 Sept 2026· Neuroscience· PUBMED
Publication
D-Cycloserine ameliorates innate fear deficits in young adult male APP/PS1 mice: Involvement of GluN2B-containing NMDA receptor.
19 Sept 2026· Pharmacology, biochemistry, and behavior· PUBMED
Publication
Nursing care of a pediatric patient with anti-NMDAR encephalitis complicated by secondary epilepsy: A case report.
18 Sept 2026· Medicine· PUBMED
Publication
Mechanisms of NMDA receptor inhibition by fluoroethylnormemantine - comparison with memantine.
11 Sept 2026· European journal of pharmacology· PUBMED
Publication
Curcumin attenuates NMDA Receptor Phosphorylation on Glutamatergic Terminals and Lowers Blood Pressure in Obese Postmenopausal Mice.
7 Sept 2026· The Journal of nutrition· PUBMED
Publication
Ovariectomy reverses maternal immune activation-induced deficits in dopamine and NMDA receptor-mediated regulation of prepulse inhibition in female Long-Evans rats.
7 Sept 2026· Schizophrenia research· PUBMED
Publication
NMDA subunit 2B-selective negative allosteric modulator satoprodil (BI 1569912) as mono- and adjunctive therapy in patients with major depressive disorder: results from two phase 2 randomized, controlled trials.
5 Sept 2026· Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology· PUBMED
Publication
NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration.
1 Sept 2026· Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology· PUBMED
Publication
Selective mGlu1 Receptor Activation Restores Cortical Inhibitory Tone and Improves Cognitive Performance in a Subchronic Phencyclidine NMDA Hypofunction Model.
1 Sept 2026· Biological psychiatry global open science· PUBMED
Publication
Ferroptosis and NMDA Receptor Activity in Alzheimer's Disease: Implications for Amyloid Pathology and P-Glycoprotein Regulation.
1 Sept 2026· Drug development research· PUBMED
Publication
Structural and mechanistic insights into gating and allosteric modulation of GluN1-GluN3A NMDA receptors.
28 Aug 2026· Nature structural & molecular biology· PUBMED
Publication
A Dual Prediction Error Populations Model of Schizophrenia Spectrum Disorders: Bridging NMDA Hypofunction and Gain Hyperfunction.
20 Aug 2026· Schizophrenia bulletin· PUBMED
Publication
Efgartigimod as a salvage therapy for anti-NMDAR encephalitis patients after first-line treatment failure: a case series.
14 Aug 2026· Frontiers in neurology· PUBMED
Publication
Targeting NMDA Receptor Pathways in Alzheimer's Disease, From Cellular Mechanisms to Treatment Strategies.
13 Aug 2026· Current neuropharmacology· PUBMED
Publication
NMDA receptor subunit-dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons.
13 Aug 2026· British journal of pharmacology· PUBMED
Publication
Development of glutamatergic antipsychotics requires efficient synaptic glutamatergic transmission while preventing NMDA receptor down-regulation and overactivation of extrasynaptic transmission.
13 Aug 2026· British journal of pharmacology· PUBMED
Publication
Corticostriatal glutamate mechanisms underlying beta synchrony and motor deficits via striatal NMDA receptors in Parkinson's disease.
11 Aug 2026· EBioMedicine· PUBMED
Publication
Redox Homeostasis and Oxidative Stress in Schizophrenia: Glutathione-NMDA-Neuroimmune Convergence and a Hypothesis-Generating Iron-Lipid Redox Extension.
8 Aug 2026· International journal of molecular sciences· PUBMED
Preprint
Sex-divergent trajectories of hippocampal and cortical NMDA receptor density across the Alzheimer's disease continuum.
6 Aug 2026· bioRxiv : the preprint server for biology· PUBMED

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