Target

NOTCH3

Neurogenic locus notch homolog protein 3

3open trials
3trials in total
41publications
0researchers

Diseases

Stroke1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Correction: NRF2 signaling plays an essential role in cancer progression through the NRF2-GPX2-NOTCH3 axis in head and neck squamous cell carcinoma.
19 Oct 2026· Oncogenesis· PUBMED
Publication
Interaction Between Age and the NOTCH3 p.R544C Variant in Determining Ischemic Stroke Risk: Insights from the Taiwan Biobank Study of 8,588 Patients.
24 Sept 2026· International journal of medical sciences· PUBMED
Publication
LncRNA RAMS11-dependent NOTCH3 activation drives tumor progression in non-small cell lung cancer.
8 Sept 2026· NAR cancer· PUBMED
Publication
Potential contributors to variable penetrance of NOTCH3 p.Arg1231Cys Variant.
2 Sept 2026· Neurogenetics· PUBMED
Publication
NOTCH3 disrupts the osteoblast transcriptome in femoral bone of 1-month-old male C57BL/6 mice.
31 Aug 2026· Bone· PUBMED
Publication
NOTCH3 Mutations in CADASIL Alter Lipid Metabolism: Insights from Patient Plasma and In Vitro Models.
21 Aug 2026· Neurochemical research· PUBMED
Publication
A NOTCH3 p.Gly1105Cys variant in CADASIL: clinical characterization and an updated overview of exon 20 variants.
31 Jul 2026· Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· PUBMED
Publication
Cortical correlates of apathy in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy with two different pathogenic mutations in the NOTCH3 gene.
15 Jun 2026· Neuropsychology· PUBMED
Publication
NOTCH3 regulates myofibroblastic CAF differentiation via the P62-ROS signaling axis to promote bladder cancer progression.
6 Jun 2026· Journal of experimental & clinical cancer research : CR· PUBMED
Publication
NOTCH3 signal activation by its extracellular domain accumulation in an iPSC line newly established from a CADASIL patient.
24 May 2026· Human cell· PUBMED
Publication
Novel Mutation of NOTCH3 Gene in a Chinese Patient with CADASIL.
14 May 2026· Balkan journal of medical genetics : BJMG· PUBMED
Publication
A novel missense variant Cys559Gly in NOTCH3 in CADASIL family and vascular lesions in patients with migraine.
13 May 2026· Postepy psychiatrii neurologii· PUBMED
Publication
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL.
6 May 2026· Annals of clinical and translational neurology· PUBMED
Publication
NOTCH3-R544C mutation drives endothelial dysfunction through inflammation, migration impairment, and lipid dysregulation.
21 Apr 2026· Journal of Alzheimer's disease : JAD· PUBMED
Publication
NOTCH3 R545C mutation drives vascular-neuronal dysfunction and cognitive impairment in CADASIL pathogenesis.
17 Apr 2026· Neurobiology of disease· PUBMED
Publication
Prognostic Significance of NOTCH3 Small Vessel Disease Staging for the NOTCH3 p.R544C Variant.
13 Apr 2026· Neurology. Genetics· PUBMED
Publication
Homozygous NOTCH3 c.3373G > A (p.(Glu1125Lys)) in a consanguineous Chinese family presenting with vestibular migraine and epilepsy: Expanding the genotype-phenotype spectrum.
9 Apr 2026· Neurogenetics· PUBMED
Publication
Functional analysis of the human miRNome in non-small cell lung cancer unveils a novel miR-92b-3p/NOTCH3 axis that drives tumor progression.
8 Apr 2026· Cell death & disease· PUBMED
Publication
An in trans NOTCH3 loss-of-function variant modifies disease severity in CADASIL: A family-based study.
7 Apr 2026· Journal of the Chinese Medical Association : JCMA· PUBMED
Publication
Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.
3 Apr 2026· Science advances· PUBMED
Publication
NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process.
31 Mar 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
Tumor-derived JAG2 programs macrophages via NOTCH3 to drive perineural invasion in colorectal cancer.
29 Mar 2026· International journal of biological macromolecules· PUBMED
Trial
Long-term Prospective Study of Korean CADASIL Patients
27 Mar 2026· NA · RECRUITING· CTGOV
Publication
3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease.
26 Mar 2026· Stem cell reports· PUBMED
Publication
Cysteine-reactive mitigators of small vessel disease-related NOTCH3 mutants.
20 Mar 2026· Scientific reports· PUBMED
Publication
Spatial multi-omics identifies a NOTCH3-mediated capillary-mCAF crosstalk driving immune exclusion in hepatocellular carcinoma.
17 Mar 2026· iMeta· PUBMED
Publication
NOTCH3 Mutations in CADASIL: a multicellular perspective on neurodegeneration.
3 Mar 2026· Cell communication and signaling : CCS· PUBMED
Publication
NOTCH3 Pathogenic Variant and Risk of Age-Related Macular Degeneration: Findings From the Taiwan Biobank and Small Vessel Disease Registry.
2 Mar 2026· Investigative ophthalmology & visual science· PUBMED
Publication
NOTCH3 attenuates cytotoxicity via RBPJ-dependent PVR upregulation to influence immunotherapy outcomes in colorectal cancer.
23 Feb 2026· Frontiers in immunology· PUBMED
Publication
Systems medicine approach unravels MMP2 and NOTCH3 as key mediators of cigarette smoke-induced airway remodelling in COPD.
2 Feb 2026· Computers in biology and medicine· PUBMED

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