2022-502316-36-00CompletedPhase 4

Mavacamten Impact on Myocardial Structure in Obstructive Hypertrophic Cardiomyopathy

MEMENTO-A Phase 3b/4 Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy to assess the impact on Myocardial Structure with Cardiac Magnetic Resonance Imaging (CMR)

Source: EU CTIS (euclinicaltrials.eu) · Last updated 12 Feb 2024

Next steps

Brief summary (registry, in English)

The purpose of this study is to see if mavacamten treatment reduces the heart wall (ventricle) thickness and size of the upper heart chamber (atria) on imaging studies by cardiac magnetic resonance (CMR).

Status (registry): Completed
Phase (registry): Phase 4
Study type: Interventional
Enrollment: 105 (actual)
First submitted: 28 Sept 2023
Start date: 20 Nov 2023
Lead sponsor: Myokardia Inc.
Diseases: Hypertrophic cardiomyopathy
EU CT number: 2022-502316-36-00

What you commit to

Study type: Interventional · Phase 4
Participants enrolled: 105
50 sites in 11 countries
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.

Who cannot take part

Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.

Other

Adults with no symptomatic oHCM (NYHA Funtional Class II or III)

Who the study is looking for

This trial will assess elegible adults with symptomatic oHCM (NYHA Funtional Class II or III)

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on EU CTIS (euclinicaltrials.eu)

Sites (50)

Sites in registry order. Save your city in your profile to sort them by distance.

Site	City	Country	Site status
A.O. Krankenhaus St. Josef Braunau GmbH	Braunau Am Inn	Austria	Completed
Medical University of Graz	Graz	Austria	Completed
Landeskrankenanstalten-Betriebsgesellschaft Kabeg	Klagenfurt Am Woerthersee	Austria	Completed
Medical University of Vienna	Vienna	Austria	Completed
Klinik Favoriten	Vienna	Austria	Completed
Hopital Erasme	Anderlecht	Belgium	Completed
UZ Brussel	Jette	Belgium	Completed
UZ Leuven	Leuven	Belgium	Completed
Algemeen Ziekenhuis Delta	Roeselare	Belgium	Completed
Cliniques Universitaires Saint-Luc	Sint-Lambrechts-Woluwe	Belgium	Completed
Fakultni Nemocnice U Sv Anny V Brne	Brno-Stred	Czechia	Completed
Nemocnice AGEL Trinec-Podlesi a.s.	Konska	Czechia	Completed
Herz Und Diabeteszentrum NRW Bad Oeynhausen Universitaetsklinik Der Ruhr-Universitaet Bochum	Bad Oeynhausen	Germany	Completed
Charite Universitaetsmedizin Berlin KöR	Berlin	Germany	Completed
Justus-Liebig-Universitaet Giessen	Giessen	Germany	Completed
Universitaetsmedizin Goettingen	Goettingen	Germany	Completed
Hospital Universitari Vall d'Hebron	Barcelona	Spain	Completed
Hospital Universitario Ramón y Cajal	Madrid	Spain	Completed
Hospital Universitario Puerta de Hierro de Majadahonda	Majadahonda	Spain	Completed
Hospital Universitario Virgen de la Victoria	Málaga	Spain	Completed
Hospital Son Llatzer	Palma	Spain	Completed
Area De Salud De Salamanca	Salamanca	Spain	Completed
University Hospital Virgen Del Rocio S.L.	Sevilla	Spain	Completed
HUS Helsinki University Hospital	Helsinki	Finland	Completed
Turku University Hospital	Turku	Finland	Completed
Centre Hospitalier Universitaire Grenoble Alpes	Grenoble Cedex 9	France	Completed
Assistance Publique Hopitaux de Paris	Paris	France	Completed
Centre Hospitalier Universitaire de Bordeaux	Pessac	France	Completed
Centre Hospitalier Universitaire de Rennes	Rennes	France	Completed
Hippokration Hospital	Athens	Greece	Completed
University General Hospital Attikon	Athens	Greece	Completed
University General Hospital of Heraklion	Heraklion	Greece	Completed
Onassis Cardiac Surgery Center	Kallithea	Greece	Completed
University General Hospital of Thessaloniki - AHEPA	Thessaloniki	Greece	Completed
Hippokration Hospital	Thessaloniki	Greece	Completed
Balatonfueredi Allami Szivkorhaz	Balatonfured	Hungary	Completed
Gottsegen National Cardiovascular Center	Budapest	Hungary	Completed
Semmelweis University	Budapest XII	Hungary	Completed
Central Hospital Of Northern Pest Military Hospital	Budapest XIII	Hungary	Completed
University of Pecs	Pécs	Hungary	Completed
University of Szeged	Szeged	Hungary	Completed
Azienda USL Toscana Sud Est	Arezzo	Italy	Completed
Careggi University Hospital	Florence	Italy	Completed
Istituto Auxologico Italiano	Milan	Italy	Completed
ASST Grande Ospedale Metropolitano Niguarda	Milan	Italy	Completed
Fondazione IRCCS Policlinico San Matteo	Pavia	Italy	Completed
Fondazione Toscana Gabriele Monasterio	Pisa	Italy	Completed
Kardio Brynów Sp. z o.o.	Katowice	Poland	Withdrawn
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji	Warsaw	Poland	Withdrawn
Śląskie Centrum Chorób Serca w Zabrzu	Zabrze	Poland	Withdrawn

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