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Taking people in BelgiumPhase 2

Tests a PSMA PET scan for imaging liver cancer in adults

Compares a PSMA PET scan with other scans to image hepatocellular carcinoma in adults.

Key facts

Who runs it
Universitair Ziekenhuis Gent
Where
Gent, BelgiumSee the site
Registry title
F-18 PSMA-11 PET for Imaging and Staging of Hepatocellular carcinoma with Evaluation of Survival
Status
Recruiting
Phase
Phase 2
People taking part
32 people, planned
Started
31 Jul 2026
Expected to end
1 Aug 2029
Type of study
Interventional
Record updated
30 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with hepatocellular carcinoma (liver cancer), either newly diagnosed with a high risk of spread or already known and needing new staging scans.

Age
18 years or older
Sex
Men and women can join
Disease stage
New diagnosis of hepatocellular carcinoma with portal invasion or a main tumour larger than 5 cm (2 in), or known disease needing restaging (unexplained raised AFP, known metastases, planned immunotherapy, or waiting for a liver transplant)

Main reasons for not taking part

  • Another active cancer besides hepatocellular carcinoma
  • History of prostate cancer
  • Currently pregnant
  • Possibly pregnant and refuses a urine pregnancy test

The registry criteria, word for word

Show all 7 criteriaShow less

Who can take part

  • Willing and mentally legally capable to provide written informed consent
  • 18 years of age or older
  • One of the following clinical scenario’s: • New diagnosis of HCC, confirmed either by biopsy or imaging using EASL/AASLD criteria, with a high risk of metastases indicated by portal invasion or a primary lesion of >5cm diameter. • Known diagnosis of HCC that requires restaging due to unexplained elevated AFP tumor markers, known metastases, impending initiation of immunotherapy, or being on the waiting list for a liver transplant; Have either planned or recently undergone (within the past 4 weeks) both F-18 FDG PET/CT and F-18 Choline PET/CT scans as part of their diagnostic or staging workup for one of the above indications

Who cannot take part

  • Known active malignancy other than hepatocellular carcinoma
  • History of prostate cancer
  • Active pregnancy
  • Possible pregnancy and refusal of urine pregnancy test

Where in Belgium

  • Universitair Ziekenhuis GentGent, BelgiumTaking people

About the trial

What the trial wants to find out

To determine the diagnostic accuracy of F-18 PSMA-11 PET/CT for the (re)staging of hepatocellular carcinoma (HCC) compared to F-18 FDG PET/CT and F-18 Choline PET/CT.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record

Print a page for my doctor

Data and sources

Registry record
Listed on the EU's official list of trials (CTIS).
Official title
F-18 PSMA-11 PET for Imaging and Staging of Hepatocellular carcinoma with Evaluation of Survival
Plain-language title
Tests a PSMA PET scan for imaging liver cancer in adultsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 9 November 2026.
Record updated
30 September 2026