Compares two ways of keeping patients calm during stroke clot removal

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults having a stroke caused by a blocked brain artery, who are treated by removing the clot through a catheter (mechanical thrombectomy). It compares sedation with a high-flow nasal cannula against general anesthesia.

Age

18 years or older

Sex

All sexes can join.

Disease stage

Stroke in the front part of the brain circulation, with a blocked internal carotid artery or middle cerebral artery (M1 or M2). Stroke severity score (NIHSS) from 6 to 25. Less than 6 hours from first symptoms to arrival at the radiology ward, or less than 24 hours since last seen without symptoms if salvageable brain tissue is shown on imaging.

Main reasons for not taking part

• Coma on admission (Glasgow Coma Scale below 8)
• Severe dependency before the stroke (mRS above 3)
• Severe agitation, or loss of airway protection reflexes or vomiting on admission
• Known or suspected difficult airway, or fasting not kept (6 hours of solids, 2 hours of clear liquids)
• Brain bleeding, platelets below 50,000, or severe blood clotting problems

The registry criteria, word for word

What the trial wants to find out

The primary objective of the study is to assess the time from hospital arrival to revascularization in patients with acute ischemic stroke treated with mechanical thrombectomy, depending on whether the procedure was performed under sedation with HFNC or under general anesthesia.