2024-512491-35-00RecruitingPhase 2
Chronic kidney disease – imaging the metabolic derangements with ultra-sensitive MRI
Source: EU CTIS (euclinicaltrials.eu) · Last updated 3 Jun 2026
Brief summary (registry, in English)
In this study, we aim to assess the metabolic signature of CKD and PDK using multi-parametric MRI. The study will include healthy volunteers (N=8), CKD patients (N=12), PKD patients (N=10). PDK patients: a. The metabolic shift towards glycolysis compared with healthy kidneys can be detected using MRI with hyperpolarized pyruvate. CKD patients a. Multi-parametric MRI combined with hyperpolarized pyruvate MRI can detect the metabolic alterations, including upregulated lactate and alanine production, associated with CKD. b. These alterations correlate with measures of fibrosis and inflammation from biopsies
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 29 May 2024
- Start date
- 1 Apr 2024
- Lead sponsor
- Aarhus Universitet
- Diseases
- Polycystic kidney disease
- EU CT number
- 2024-512491-35-00
- EudraCT number
- 2021-002551-11
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 40
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- Contraindications for MRI: - Significant cardiac disease such as severe left ventricular outflow obstruction - Significant obstructive lung disease or severe asthma - Pacemaker, neurostimulator or cholera implant - Metal foreign bodies such as fragments and irremovable piercings - Unsafe medical implants (safety of heart valves, hips and the like must be confirmed) - Claustrophobia - Largest circumference including arms > 160 cm
- Competing renal or systemic disease (except unspecific renal MRI findings, hypertension, atherosclerosis, well-regulated diabetes and hyperlipidemia/cholesterolemia which are allowed)
- Renovascular disease
- Allergy to pyruvate
Who the study is looking for
- Aged 18 – 85 years (all participants)
- Pre-menopausal women must be confirmed non-pregnant by an onsite test. (All female participants)
- Autosomal dominant polycystic kidney disease. (PKD group)
- CKD for any reason except PKD. (CKD group)
- Recent biopsy (within 6 months of MRI). (CKD group)
- eGFR > 60 (PKD patients)
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aarhus Universitet | Aarhus N | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.