2024-514740-82-00RecruitingPhase 4
SIMBA
Subcutaneous vedolizumab drug de-escalation in inflammatory bowel disease: a multicentre randomised controlled study
Source: EU CTIS (euclinicaltrials.eu) · Last updated 28 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Evaluating the effectiveness of subcutaneous vedolizumab dose de-escalation
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 278 (estimated)
- First submitted
- 18 Nov 2024
- Start date
- 16 Jul 2025
- Lead sponsor
- Stichting Amsterdam UMC
- Diseases
- Crohn's disease
- EU CT number
- 2024-514740-82-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 278
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- Use of corticosteroïds, active fistula or need for IBD-related surgery
Who the study is looking for
- Adults diagnosed with Crohn's Disease or Ulcerative Colitis in steroïd-free clinical and biochemical remission treated with bi-weekly subcutaneous vedolizumab for six or more months
Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Amsterdam UMC | Amsterdam | Netherlands | Recruiting |
| UMC Groningen | Groningen | Netherlands | Recruiting |
| Leids Universitair Medisch Centrum (LUMC) | Leiden | Netherlands | Recruiting |
| Maastricht University Medical Center | Maastricht | Netherlands | Recruiting |
| Radboud Universitair Medisch Centrum (Radboudumc) | Nijmegen | Netherlands | Recruiting |
| Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) | Rotterdam | Netherlands | Recruiting |
| Universitair Medisch Centrum Utrecht | Utrecht | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.