2024-516438-36-00Active, not recruitingPhase 2
A phase II, open-label, single arm study to evaluate the efficacy of Luspatercept in Erythropoiesis-stimulating agent naive lower-risk MDS patients with or without ring sideroblasts who do not require RBC transfusions
A phase II, open-label, single arm study to evaluate the efficacy of Luspatercept in Erythropoiesis-stimulating agent naive lower-risk MDS patients with or without ring sideroblasts who do not require RBC transfusions (LENNON)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 9 Jul 2026
Brief summary (registry, in English)
To evaluate the erythroid response (hematologic improvement erythroid, HI-E) rate of luspatercept (LUS) for the treatment of anemia due to very low-, low-, or intermediate-risk MDS in subjects who require no RBC transfusions.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 5 Aug 2024
- Start date
- 13 Sept 2022
- Lead sponsor
- Universitaet Leipzig
- Diseases
- Myelodysplastic syndromes
- EU CT number
- 2024-516438-36-00
- EudraCT number
- 2020-005219-30
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 30
- 24 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior allogeneic or autologous stem cell transplant
- Prior ESA treatment
Other illness
- Known clinically significant anemia due to iron, vitamin B12, or folate deficiencies, or autoimmune or hereditary hemolytic anemia, or gastrointestinal bleeding
Other
- Secondary MDS
- ECOG > 2
Who the study is looking for
- Diagnosis of MDS according to WHO classification
- Very low-, low-, or intermediate-risk disease with up to 3.5 score points according to revised International Prognostic Scoring System (IPSS-R) classification
- Non-transfusion dependence (NTD) according to IWG 2018
- Symptomatic anemia: mean baseline Hb < 10 g/dL
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (24)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitaetsklinikum Bonn AöR | Bonn | Germany | Active, not recruiting |
| Carl-Thiem-Klinikum Cottbus gGmbH | Cottbus | Germany | Active, not recruiting |
| OncoSearch Institut für klinische Studien GbR | Erlangen | Germany | Active, not recruiting |
| St. Franziskus Hospital Flensburg | Flensburg | Germany | Active, not recruiting |
| Universitaetsmedizin Goettingen | Goettingen | Germany | Active, not recruiting |
| Universitaetsmedizin Greifswald KöR | Greifswald | Germany | Active, not recruiting |
| OncoResearch Lerchenfeld GmbH | Hamburg | Germany | Active, not recruiting |
| Onkologie am Raschplatz Dr. Ingo Zander & Dr. Eyck von der Heyde | Hannover | Germany | Active, not recruiting |
| Klinikum Kassel GmbH | Kassel | Germany | Active, not recruiting |
| VK&K Studien GbR | Landshut | Germany | Active, not recruiting |
| Universitaet Leipzig | Leipzig | Germany | Active, not recruiting |
| Universitaetsklinikum Magdeburg AöR | Magdeburg | Germany | Active, not recruiting |
| Universitaetsklinikum Mannheim GmbH | Mannheim | Germany | Active, not recruiting |
| Mannheimer Onkologie Praxis | Mannheim | Germany | Active, not recruiting |
| Klinikum Hochsauerland GmbH | Meschede | Germany | Active, not recruiting |
| Kliniken Maria Hilf GmbH Moenchengladbach | Moenchengladbach | Germany | Active, not recruiting |
| Universitaetsklinikum Muenster AöR | Muenster | Germany | Active, not recruiting |
| Haematologie und Onkologie Muenchen-Pasing MVZ GmbH | Munich | Germany | Active, not recruiting |
| Klinikum rechts der Isar der TU Muenchen AöR | Munich | Germany | Active, not recruiting |
| Onkologie/Haematologie Rhein Ruhr Dr. med. Steiniger und Schneider Partnerschaft von Aerzten | Oberhausen | Germany | Active, not recruiting |
| Zentrum Fuer Innere Medizin | Rostock | Germany | Active, not recruiting |
| Praxis für Hämatologie und Onkologie | Saarbrücken | Germany | Active, not recruiting |
| Klinikum Mutterhaus der Borromaeerinnen gGmbH | Trier | Germany | Active, not recruiting |
| Universitaetsklinikum Tuebingen AöR | Tuebingen | Germany | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.