Under construction – not a live service
Sign in
Taking people in DenmarkPhase 2

MRI Scans Using Hyperpolarized Pyruvate in ALS and Transient Ischemic Attack

Tests a new MRI scan to detect metabolic problems in adults with ALS or TIA.

Key facts

Who runs it
Aarhus Universitet
Where
Aarhus N, DenmarkSee the site
Registry title
MRI of Neurometabolic Impairment in ALS and TIA Using Hyperpolarized Pyruvate
Status
Recruiting
Phase
Phase 2
People taking part
46 people, planned
Started
1 May 2020
Expected to end
1 Jan 2029
Type of study
Interventional
Record updated
29 July 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with ALS or a recent transient ischemic attack (TIA, a short stroke-like episode) to study brain metabolism with a new MRI technique.

Age
18-85 years
Sex
All sexes. Women before menopause must have a negative pregnancy test done at the site.
Disease stage
ALS group: meets the 2021 Gold Coast criteria and has upper motor neuron symptoms. TIA group: TIA within the last 10 days, with weakness of one limb or one side of the face lasting at least 10 minutes.

Main reasons for not taking part

  • Chronic kidney disease
  • Significant heart disease or significant obstructive lung disease or severe asthma
  • Pacemaker, neurostimulator, metal foreign bodies, unsafe implants, or intracranial clips or coils
  • Claustrophobia, or body circumference including arms over 160 cm (5 ft 3 in)
  • Allergy to pyruvate

The registry criteria, word for word

Show all 2 criteriaShow less

Who can take part

  • All participants: 1) Age 18-85 years. 2) Pre-menopausal women must be confirmed non-pregnant by an onsite test. ALS group: 1) Fulfilling the 2021 Gold Coast criteria. 2) Upper motor neuron symptoms. TIA-group: 1) TIA within the last 10 days. 2) Symptoms must include unilateral weakness of limb or face. 3) Duration af symptoms minimum 10 minutes

Who cannot take part

  • Contraindications for MRI with contrast: Chronic kidney disease,- Significant cardiac disease such as severe left ventricular outflow obstruction, -Significant obstructive lung disease or severe asthma,- Pacemaker, neurostimulator or cholera implant,- Metal foreign bodies such as fragments and irremovable piercings,- Unsafe medical implants (safety of heart valves, hips and the like must be confirmed),- Intracranial clips or coils,- Claustrophobia,- Largest circumference including arms > 160 cm. Competing neurological, psychiatric, liver or systemic disease including diabetes (except prior TIA, unspecific brain MRI findings, hypertension, atherosclerosis and hyperlipidemia/cholesterolemia which are allowed). Allergy to pyruvate

Where in Denmark

  • Aarhus UniversitetAarhus N, DenmarkTaking people

About the trial

What the trial wants to find out

This project seeks to detect and characterize metabolic impairment in patients with Amyotrophic Lateral Sclerosis and patients with Transient Ischemic attack with a new MRI technique termed Hyperpolarized Pyruvate MRI

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record

Print a page for my doctor

Data and sources

Registry record
Listed on the EU's official list of trials (CTIS).
Official title
MRI of Neurometabolic Impairment in ALS and TIA Using Hyperpolarized Pyruvate
Plain-language title
MRI Scans Using Hyperpolarized Pyruvate in ALS and Transient Ischemic AttackGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 9 November 2026.
Record updated
29 July 2026