MRI Scans Using Hyperpolarized Pyruvate in ALS and Transient Ischemic Attack
Tests a new MRI scan to detect metabolic problems in adults with ALS or TIA.
Plain-language title generated from the registry record
Registry title: MRI of Neurometabolic Impairment in ALS and TIA Using Hyperpolarized Pyruvate
Key facts
- Where
- Aarhus N, DenmarkSee the site
- Phase
- Phase 2
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with ALS or a recent transient ischemic attack (TIA, a short stroke-like episode) to study brain metabolism with a new MRI technique.
- Age
- 18-85 years
- Sex
- All sexes. Women before menopause must have a negative pregnancy test done at the site.
- Disease stage
- ALS group: meets the 2021 Gold Coast criteria and has upper motor neuron symptoms. TIA group: TIA within the last 10 days, with weakness of one limb or one side of the face lasting at least 10 minutes.
Main reasons for not taking part
- Chronic kidney disease
- Significant heart disease or significant obstructive lung disease or severe asthma
- Pacemaker, neurostimulator, metal foreign bodies, unsafe implants, or intracranial clips or coils
- Claustrophobia, or body circumference including arms over 160 cm (5 ft 3 in)
- Allergy to pyruvate
Read by machine on 9 November 2026.
Where in Denmark
- Aarhus UniversitetAarhus N, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record
Print a page for my doctorTrial details
- Who runs it
- Aarhus Universitet
- Trial code
- EU 2024-516954-24-00
- Record updated
- 29 July 2026
- Original description
This project seeks to detect and characterize metabolic impairment in patients with Amyotrophic Lateral Sclerosis and patients with Transient Ischemic attack with a new MRI technique termed Hyperpolarized Pyruvate MRIRead full original descriptionShow less
MRI of Neurometabolic Impairment in ALS and TIA Using Hyperpolarized Pyruvate
This project seeks to detect and characterize metabolic impairment in patients with Amyotrophic Lateral Sclerosis and patients with Transient Ischemic attack with a new MRI technique termed Hyperpolarized Pyruvate MRI
Inclusion: All participants: 1) Age 18-85 years. 2) Pre-menopausal women must be confirmed non-pregnant by an onsite test. ALS group: 1) Fulfilling the 2021 Gold Coast criteria. 2) Upper motor neuron symptoms. TIA-group: 1) TIA within the last 10 days. 2) Symptoms must include unilateral weakness of limb or face. 3) Duration af symptoms minimum 10 minutes.
Exclusion: Contraindications for MRI with contrast: Chronic kidney disease,- Significant cardiac disease such as severe left ventricular outflow obstruction, -Significant obstructive lung disease or severe asthma,- Pacemaker, neurostimulator or cholera implant,- Metal foreign bodies such as fragments and irremovable piercings,- Unsafe medical implants (safety of heart valves, hips and the like must be confirmed),- Intracranial clips or coils,- Claustrophobia,- Largest circumference including arms > 160 cm. Competing neurological, psychiatric, liver or systemic disease including diabetes (except prior TIA, unspecific brain MRI findings, hypertension, atherosclerosis and hyperlipidemia/cholesterolemia which are allowed). Allergy to pyruvate.