Tests two anesthetic doses during electroconvulsive therapy for depression
Compares low and high thiopental doses in adults with major depression receiving electroconvulsive therapy.
Key facts
- Who runs it
- Karolinska Institutet
- Where
- Goteborg, Orebro, and Stockholm, SwedenSee the 3 sites
- Trial code
- Registry title
- A randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression
- Status
- Not yet recruiting
- Phase
- Phase 4
- People taking part
- 210 people, planned
- Started
- 13 Jan 2025
- Expected to end
- 31 Dec 2031
- Type of study
- Interventional
- Record updated
- 15 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for hospitalized adults with a current major depressive episode who are going to have electroconvulsive therapy (ECT). It compares a low and a high dose of the anesthetic thiopental.
- Age
- 18 years and above
- Sex
- All sexes
- Disease stage
- Hospitalized patients with an ongoing major depressive episode within major depressive disorder (MDD)
Main reasons for not taking part
- Postpartum depression
- Schizophrenia, psychotic syndrome or bipolar disorder
- The anesthesiologist judges a high anesthetic dose inappropriate because of a physical condition
- Compulsory psychiatric care under the Swedish Act on Compulsory Psychiatric Care
- Cannot speak or understand Swedish or English well enough to give consent or complete the study assessments
The registry criteria, word for word
Show all 2 criteriaShow less
Who can take part
- age 18 years and above • hospitalized patients with an ongoing major depressive episode within MDD
Who cannot take part
- postpartum depression • schizophrenia • psychotic syndrome • bipolar disorder • patients for whom the anesthesiologist deems that a high anesthetic dose is inappropriate due to a somatic condition. • patients under compulsory psychiatric care according to the Swedish Act on Compulsory Psychiatric Care (Lagen om psykiatrisk tvångsvård) • patients who do not speak or understand Swedish or English sufficiently to provide informed consent or complete study assessments
Where in Sweden
- Sahlgrenska University Hospital-Vaestra GoetalandsregionenGoteborg, SwedenNot yet recruiting
- Region Oerebro LaenOrebro, SwedenNot yet recruiting
- Region Stockholm – SLSOStockholm, SwedenNot yet recruiting
About the trial
What the trial wants to find out
The main objective of this trial is to to test if the reduction of depressive symptoms after six electroconvulsive therapy (ECT) sessions is larger in patients anesthetized with a low thiopental dose compared to patients anesthetized with a high thiopental dose during ECT.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record
Print a page for my doctorData and sources
- Registry record
- Listed on the EU's official list of trials (CTIS).
- Official title
- Thiopental Induction Dose during Electroconvulsive therapy for depression (TIDE) - a randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression
- Plain-language title
- Tests two anesthetic doses during electroconvulsive therapy for depressionGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 9 November 2026.
- Record updated
- 15 July 2026