Compares Rina-S with standard treatment in endometrial cancer that has returned or spread
Tests Rina-S against the doctor's chosen treatment in adults with advanced endometrial cancer.
Plain-language title generated from the registry record
Registry title: Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator’s Choice in Participants With Endometrial Cancer ( RAINFOL-03 )
Key facts
- Where
- Aalborg, Herlev, and Herning, DenmarkSee the 3 sites
- Phase
- Phase 3
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women with endometrial cancer that has come back or got worse after earlier treatment, including platinum chemotherapy and a PD(L)-1 inhibitor.
- Age
- 18 years or older.
- Sex
- Women only.
- Disease stage
- Recurrent or progressive endometrial cancer (any subtype except neuroendocrine tumors, carcinosarcoma or endometrial sarcoma). The cancer must have grown on scans on or after the most recent line of therapy.
- Earlier treatment
- Must have had at least 1 but not more than 3 prior lines of therapy, including platinum-based chemotherapy and a PD(L)-1 inhibitor, given separately or together. Hormonal therapy alone does not count as a line.
Main reasons for not taking part
- Earlier treatment with an antibody-drug conjugate containing a topoisomerase 1 inhibitor
- Another past or current cancer, with some exceptions such as treated early cervical cancer or non-invasive skin cancer
- Active cancer spread to the brain or spinal fluid (brain spread treated earlier and stable for at least 4 weeks is allowed)
- Hospital stay or symptoms from a bowel blockage in the past 91 days, or a bowel blockage seen on scans at screening
Read by machine on 9 November 2026.
Where in Denmark
- Aalborg University HospitalAalborg, DenmarkTaking people
- Region HovedstadenHerlev, DenmarkTaking people
- Region MidtjyllandHerning, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record
Print a page for my doctorTrial details
- Who runs it
- Genmab A/S
- Trial code
- EU 2024-519818-31-01
- Record updated
- 10 August 2026
- Original description
To compare clinical efficacy of Rina-S to treatment of investigator’s choice (IC) in patients with recurrent or progressive endometrial cancer (EC) following prior therapyRead full original descriptionShow less
A Phase 3 Randomized, Open-label Study of Rinatabart Sesutecan (Rina-S) Versus Treatment of Investigator’s Choice (IC) in Patients With Endometrial Cancer After Platinum-Based Chemotherapy and PD(L)-1 Therapy
To compare clinical efficacy of Rina-S to treatment of investigator’s choice (IC) in patients with recurrent or progressive endometrial cancer (EC) following prior therapy
Inclusion: Participants must have histologically or cytologically confirmed recurrent or progressive endometrial cancer (EC; any subtype excluding neuroendocrine tumors, carcinosarcoma, or endometrial sarcoma) following prior therapy; Participants must have received at least 1, but not more than 3, prior lines of therapy:; Participants must have received prior platinum-based chemotherapy and a programmed death (ligand)-1 (PD(L)-1) inhibitor, either separately or in combination; If the tumor recurred more than 12 months after completion of platinum-based chemotherapy, additional platinum-based chemotherapy must be administered for recurrent disease unless the participant is ineligible for further platinum-based chemotherapy, in which case the reason for ineligibility must be documented. Note: If Immunotherapy-based treatment is administered in the advanced / recurrent setting, then platinum rechallenge is not required, regardless of the duration of the platinum-free interval from prior platinum-based chemotherapy. In such cases, the reason for ineligibility for platinum-based chemotherapy must be documented; Prior induction plus maintenance is considered 1 line of therapy; Hormonal therapy alone (ie, without chemotherapy) will not be counted as a separate line of therapy; Therapy changed due to toxicity in the absence of progression will be considered part of the same line of therapy (i.e., will not be counted independently as a separate line of therapy); Participants must have progressed radiographically on or after their most recent line of therapy.
Exclusion: Prior therapy with an antibody-drug conjugate containing a topoisomerase 1 inhibitor; Has a past or current malignancy other than the inclusion diagnosis before the planned first dose of study drug, or any evidence of residual disease from a previously diagnosed malignancy. Exceptions are malignancies with a negligible risk of metastasis or death (eg, 5-year OS ≥90%), including, but not limited to, adequately treated cervical carcinoma of Stage 1B or less, noninvasive basal cell or squamous cell skin carcinoma, noninvasive superficial bladder cancer, ductal carcinoma in situ, or any past malignancy considered cured for ≥3 years (ie, eligible participants must have complete response of ≥3 years duration); Known active central nervous system metastases or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are clinically stable for at least 4 weeks prior to study entry after completion of brain metastasis treatment, they have no new or enlarging brain metastases, and are off corticosteroids and anticonvulsants prescribed for symptoms associated with brain metastases for at least 7 days prior to the planned first dose of study drug. Participants with suspected brain metastases at screening should undergo a computed tomography (CT)/magnetic resonance imaging (MRI) of the brain prior to study entry; Hospitalization or clinical symptoms due to gastrointestinal obstruction within the past 91 days or radiographic evidence of gastrointestinal obstruction at the time of screening. Enrollment of participants who currently require parenteral nutrition must be discussed with the study medical monitor to determine eligibility.