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Taking people in AustriaPhase 2

Tests cangrelor during emergency stroke treatment with carotid artery stenting

Tests cangrelor in adults with a blocked brain artery stroke and narrowed neck artery.

Key facts

Who runs it
Medical University Of Graz
Where
Graz, Innsbruck, and Salzburg, AustriaSee the 3 sites
Registry title
Cangrelor in endovascular stroke treatment with emergent carotid artery stenting (CANCAS)
Status
Recruiting
Phase
Phase 2
People taking part
50 people, planned
Started
6 Nov 2025
Expected to end
30 Nov 2027
Type of study
Interventional
Record updated
22 July 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults having an acute stroke caused by a blocked large artery in the front of the brain, who also have a narrowed neck artery needing a stent.

Age
18 years or older
Sex
All sexes can join.
Disease stage
Acute stroke with a blocked large artery in the front of the brain (carotid artery territory), plus narrowing of 50% or more of the carotid artery on the same side from atherosclerosis. Clot removal (mechanical thrombectomy) and emergency carotid artery stenting are needed.
Earlier treatment
People cannot join if they are on active P2Y12 inhibitor treatment (for example Clopidogrel, Ticagrelor, Prasugrel) or on oral anticoagulants at a therapeutic dose.

Main reasons for not taking part

  • Carotid artery narrowing not caused by atherosclerosis (for example dissection)
  • Known pregnancy; women who could become pregnant need a negative pregnancy test
  • High risk of bleeding in or outside the skull, as judged by the stroke doctors
  • Uncontrolled high blood pressure
  • Known allergy to any of the medicines used, or taking part in another interventional trial at the same time

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Adult patients (≥18 years of age)
  • Large vessel occlusion stroke of the anterior cerebral circulation (carotid artery territory)
  • Concomitant ipsilateral atherosclerotic carotid artery stenosis ≥50% requiring mechanical thrombectomy and emergent carotid artery stenting

Who cannot take part

  • Active pre-treatment with a P2Y12 inhibitor (e.g. Clopidogrel, Ticagrelor, Prasugrel
  • Pre-treatment with oral anticoagulants in a therapeutic dosage
  • Prohibited concomitant therapies
  • High intra- or extracranial bleeding risk according to the judgement of the treating stroke physicians (history of severe bleeding disorders, known haemophilia, severe liver disease, thrombocytopenia <100,000/µL, coagulation factor abnormalities, recent major surgery, recent major trauma, large brain infarct size
  • Uncontrolled hypertension
  • The patient’s medical history reveals a known allergy to any of the medications being used or their constituents, or to medications with a similar chemical structure
  • Non-atherosclerotic carotid artery stenosis (e.g. dissection)
  • Known pregnancy (for women with childbearing potential a negative pregnancy test is required)
  • Simultaneous participation in another interventional clinical trial

Where in Austria

  • Medical University of GrazGraz, AustriaTaking people
  • Medizinische Universitaet InnsbruckInnsbruck, AustriaTaking people
  • Gemeinnuetzige Salzburger Landeskliniken Betriebsgesellschaft mbHSalzburg, AustriaTaking people

About the trial

What the trial wants to find out

To assess the safety and efficacy of IV Cangrelor in patients with acute ischaemic stroke and large vessel occlusion of the intracranial carotid artery or first two segments of the middle cerebral artery (carotid artery territory) and concomitant symptomatic atherosclerotic extracranial carotid artery stenosis (≥50%) requiring mechanical thrombectomy and emergent extracranial carotid artery stenting.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record

Print a page for my doctor

Data and sources

Registry record
Listed on the EU's official list of trials (CTIS).
Official title
Cangrelor in endovascular stroke treatment with emergent carotid artery stenting (CANCAS)
Plain-language title
Tests cangrelor during emergency stroke treatment with carotid artery stentingGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 9 November 2026.
Record updated
22 July 2026