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Taking people in NetherlandsPhase 3

Brain imaging and blood tests in people with long-lasting post-COVID symptoms

Compares brain scans and blood markers in adults with and without post-COVID symptoms.

Key facts

Who runs it
Amsterdam UMC Stichting
Where
Amsterdam, NetherlandsSee the site
Registry title
Post-INFECT: Investigating Neuroinflammation and its effects in post-COVID syndrome
Status
Recruiting
Phase
Phase 3
People taking part
65 people, planned
Started
5 Jul 2026
Expected to end
31 Dec 2026
Type of study
Interventional
Record updated
1 June 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 30-65 who had mild COVID-19 at least one year ago. Some have lasting post-COVID complaints and some do not.

Age
30-65 years (the registry also lists 18 Years to 64 Years).
Sex
All sexes can join.
Disease stage
Mild symptomatic COVID-19 diagnosed at least one year ago. One group has severe fatigue (CIS-fatigue 35 or more) and/or difficulty concentrating (CIS-concentration 18 or more). The control group has no fatigue (below 35) and no concentration difficulty (below 18).
Earlier treatment
People actively using anti-inflammatory drugs cannot join.
Biomarker or test result
COVID-19 confirmed by a positive PCR for SARS-CoV-2, positive SARS-CoV-2 serology, CO-RADS 4 or 5 on CT-scan, or antigen quicktest. Or typical symptoms in a household where another person tested positive by PCR.

Main reasons for not taking part

  • Cannot lie still for scanning (claustrophobia, severe back pain or fear of needles)
  • Women who could become pregnant and are not surgically sterile, not abstaining or not using reliable contraception
  • Women who are pregnant or breastfeeding
  • A known psychiatric, physical or neurodegenerative condition that could explain the complaints
  • Actively using anti-inflammatory drugs

The registry criteria, word for word

Show all 9 criteriaShow less

Who can take part

  • The subject was diagnosed with mild symptomatic COVID-19, confirmed by a positive PCR for SARS- CoV-2, positive SARS-CoV-2 serology or CO-RADS (COVID-19 Reporting and Data System) 4 or 5 on CT-scan, or antigen quicktest, or had typical symptoms and was part of a household in which another person was tested positive by PCR 2 weeks before or after the first day of illness
  • The subject is at least one year after being diagnosed with COVID-19
  • Subjects with persistent post-COVID complaints experience severe levels of fatigue (≥ 35) on the fatigue subscale of the Checklist Individual Strength [CIS-fatigue]) and/or difficulty concentrating (≥18) on the concentration subscale of the Checklist Individual Strength [CIS-concentration]. Control subjects without persistent complaints experiences no fatigue (<35) on the CIS-fatigue and no difficulty concentrating (<18) on the CIS-concentration
  • The subject is in the range 30-65 years of age
  • The subject has sufficient command of the Dutch language

Who cannot take part

  • The subject is actively using anti-inflammatory drugs
  • The subject has an already known psychiatric, somatic or neurodegenerative condition that can explain his/her complaints
  • The subject is unable to lay still for scanning due to claustrophobia, severe back pain or trypanophobia (fear of needles)
  • The subject is of female sex with childbearing potential and not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception. Females of childbearing potential must orally and in writing confirm not to be pregnant or breastfeeding at the time of screening and at the day of the PET scan

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 64 years old?

Where in Netherlands

  • Amsterdam UMC StichtingAmsterdam, NetherlandsTaking people

About the trial

What the trial wants to find out

To assess differences between participants with persistent post-COVID complaints and controls without persistent post-COVID complaints in cellular metabolism in the brain as measured with dynamic [18F]FDG PET, structural and functional brain parameters as assessed with MRI, and immune-related blood parameters.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record

Print a page for my doctor

Data and sources

Registry record
Listed on the EU's official list of trials (CTIS).
Official title
Post-INFECT: Investigating Neuroinflammation and its eFEcts in post-COVID syndrome: an imaging sTudy
Plain-language title
Brain imaging and blood tests in people with long-lasting post-COVID symptomsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 9 November 2026.
Fit questions
Built from 2025-522349-23-00, who can take part
Record updated
1 June 2026