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Not yet taking people in SpainPhase 4

Two nerve block approaches for pain relief after knee replacement surgery

Compares two nerve block methods for pain after knee replacement in people with knee osteoarthritis.

Key facts

Who runs it
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer
Where
Barcelona, SpainSee the site
Registry title
Adductor canal and IPACK (infiltration between the popliteal artery and the capsule of the knee) blocks versus genicular nerves block for total knee arthroplasty: A randomized clinical trial
Status
Not yet recruiting
Phase
Phase 4
People taking part
64 people, planned
Started
1 Jan 2026
Expected to end
1 Jan 2027
Type of study
Interventional
Record updated
6 February 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults having a first (primary) total knee replacement. It compares two types of nerve block for pain relief after surgery.

Age
18 to 90 years
Sex
All sexes
Disease stage
Knee osteoarthritis needing a first total knee replacement. General health class ASA I-III. BMI 18-40 kg/m2.
Earlier treatment
People who took opioids in the last 4 weeks at doses greater than 30 mg of oral morphine or equivalent cannot join.

Main reasons for not taking part

  • Surgery on both knees, a redo knee replacement, or other prosthetic replacements
  • Needing general anesthesia
  • Reasons a nerve block cannot be done, such as local infection, nerve damage, complex regional pain syndrome, or past injury or surgery on the same knee
  • Infection in the whole body, or a bleeding or clotting disorder
  • Allergy to a medicine used in the trial, such as local anesthetics

The registry criteria, word for word

Show all 13 criteriaShow less

Who can take part

  • All patients undergoing primary total knee arthroplasty who provide consent to participate in the study and whose attending surgeon also agrees to the study
  • ASA physical status classification I-III
  • BMI 18-40 kg/m2

Who cannot take part

  • Contraindication for peripheral nerve block (local infection, neurological deficit, complex regional pain syndrome, previous trauma, or surgery on the ipsilateral knee)
  • Systemic infection
  • Patients with allergies to any medication that is part of the protocol (e.g., allergy to local anesthetics)
  • Patients with a hemorrhagic diathesis or coagulopathy (diagnosed by medical history or laboratory tests)
  • Age younger than 18 years or older than 90 years
  • Patients who refuse to undergo the block procedure, who refuse to give their consent, or who are unable to cooperate with protocol compliance
  • Patients in whom the total dose of local anesthetic exceeds the calculated toxic dose based on their ideal body weight
  • Patients requiring general anesthesia
  • Patients undergoing bilateral arthroplasty, revision arthroplasties, or prosthetic replacements
  • Consumption of opioids during the last 4 weeks at doses greater than 30 mg of oral morphine or equivalent

Where in Spain

  • Hospital Clinic de BarcelonaBarcelona, SpainNot yet recruiting

About the trial

What the trial wants to find out

Compare the analgesic efficacy between Geniculate Nerve Blocks versus the combination of IPACK (infiltration between the popliteal artery and the capsule of the knee) and Adductor Canal Blocks in patients undergoing primary total knee replacement (TKR). This will be evaluated during the first physiotherapy session at 24 hours postoperatively, using the Numerical Rating Scale (NRS) for pain assessment.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record

Print a page for my doctor

Data and sources

Registry record
Listed on the EU's official list of trials (CTIS).
Official title
Adductor canal and IPACK (infiltration between the popliteal artery and the capsule of the knee) blocks versus genicular nerves block for total knee arthroplasty: A randomized clinical trial
Plain-language title
Two nerve block approaches for pain relief after knee replacement surgeryGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
6 February 2026