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Taking people in DenmarkPhase 4

Early thyroid hormone treatment after partial thyroid removal and its effect on the kidneys

Tests early levothyroxine on kidney function in adults after partial thyroid surgery.

Key facts

Who runs it
Region Midtjylland
Where
Aarhus N and Herning, DenmarkSee the 2 sites
Registry title
Impact of Early Thyroid Hormone Replacement on Kidney Function and Health-Related Quality of Life in Patients at Risk of Postoperative Hypothyroidism after Hemithyroidectomy: A Randomised Controlled Trial
Status
Recruiting
Phase
Phase 4
People taking part
56 people, planned
Started
12 Mar 2026
Expected to end
2 Aug 2027
Type of study
Interventional
Record updated
3 March 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults who are about to have their first hemithyroidectomy (removal of half of the thyroid gland) and have a TSH of at least 2 mUI/L. It tests early thyroid hormone (LT4) treatment.

Age
18 years or older
Sex
All sexes can join
Disease stage
Referred for a first hemithyroidectomy, with a TSH of 2 mUI/L or higher and eGFR (a kidney function test) above 30 mL/min/1.73m2
Earlier treatment
No previous thyroid operation. Treatment with ACE inhibitors, ARB or SGLT2 must not be started after surgery. No cancer treatment in the last three years.
Biomarker or test result
TSH 2 mUI/L or higher; eGFR above 30 mL/min/1.73m2

Main reasons for not taking part

  • A previous thyroid operation
  • A planned total thyroidectomy or completion thyroidectomy during follow-up
  • Pregnancy or plans of pregnancy after the operation
  • Cancer treatment within the last three years
  • Severe other illness, including severe heart disease or kidney disease with GFR below 30

The registry criteria, word for word

Show all 18 criteriaShow less

Who can take part

  • Patients referred for a first hemithyroidectomy
  • TSH ≥2 mUI/L
  • eGFR > 30 mL/min/1.73m2
  • Age 18 years or above
  • Ability to understand the study information and provide written informed consent
  • Able and willing to comply with study procedures and attend scheduled visits

Who cannot take part

  • Previous thyroid operation
  • Initiated treatment with either ACE inhibitors, ARB or SGLT2 after surgery
  • Treatment with Thycapzole or similar medication with direct effect on thyroid hormones
  • Concomitant operation for primary hyperparathyroidism (PHPT)
  • Cancer treatment within the last three years
  • Severe cardio-vascular disease (atrial fibrillation, heart failure etc.)
  • Severe other illness (psychiatric disorder, kidney disease with GFR < 30 etc.)
  • Inability to understand Danish or provide informed consent
  • Participation in another interventional study that may interfere with outcomes
  • Planned total thyroidectomy or completion thyroidectomy during follow-up
  • Pregnancy or plans of pregnancy in the postoperative period
  • Use of narcotics or alcohol abuse

Where in Denmark

  • Region MidtjyllandAarhus N, DenmarkTaking people
  • Region MidtjyllandHerning, DenmarkTaking people

About the trial

What the trial wants to find out

To evaluate whether postoperative treatment with LT4 leads to an improvement in kidney function - measured as change in eGFR - three months after HT, compared to standard care without LT4

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record

Print a page for my doctor

Data and sources

Registry record
Listed on the EU's official list of trials (CTIS).
Official title
Impact of Early Thyroid Hormone Replacement on Kidney Function and Health-Related Quality of Life in Patients at Risk of Postoperative Hypothyroidism after Hemithyroidectomy: A Randomised Controlled Trial
Plain-language title
Early thyroid hormone treatment after partial thyroid removal and its effect on the kidneysGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 9 November 2026.
Record updated
3 March 2026