Taking people in United StatesNo phase

Following People With Liver Disease Over Time With Check-Ups

Follows people with acute or chronic liver disease through yearly check-ups and tests.

Key facts

Who runs it: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Where: Bethesda, United StatesSee the site
Trial code: NCT00001971
Registry title: Evaluation of Patients With Liver Disease
Status: Recruiting
People taking part: 8,050 people, planned
Started: 27 May 1992
Type of study: Observational, 2 groups
Record updated: 12 November 2026

Who can take part

Age: 2 years to 100 years
Sex: Women and men
Healthy volunteers: Can take part

The registry criteria, word for word

Show all 22 criteriaShow less

Who cannot take part

Taking any regular medications or supplements (with the exception of regular multivitamins and/or oral contraceptives)
History of significant medical illnesses that might interfere with prolonged follow up evaluation; Healthy Volunteers; A healthy volunteer who meets any of the following criteria will be excluded from participation in this study:
Any chronic medical condition, including (but not limited to) heart, kidney, or lung diseases
History of liver disease (with the exception of neonatal jaundice)
History of severe illness, infection or major surgery in the past year
History of cancer (with the exception of basal cell carcinoma resected > 1 year prior to enrollment)
HIV positive, Anti-HCV positive, HBsAg positive or Anti-HBc positive
Hemoglobin < 11 (women) or hemoglobin < 12 (men)
ALT >35 (men) or ALT >25 (women)
Alkaline Phosphatase >= 150
Bilirubin >2 g/dL
Affected Participants
An affected participant who meets any of the following criteria will be excluded from participation in this study:
Average alcohol consumption > 1 drink/day in past 6 months, per self-report
BMI < 18 or BMI >25
Pregnancy
Inability to provide informed consent

Other criteria

INCLUSION CRITERIA:; Affected Subjects; In order to be eligible to participate in this study, an affected participant must meet all of the following criteria:
>=2 years of age
Meets one of the following:; Suspected or evidence of acute or chronic liver disease on evaluation by a referring licensed independent practitioner (LIP), OR; At risk for acute or chronic liver disease; Healthy Volunteers; In order to be eligible to participate in this study, a healthy volunteer must meet all of the following criteria:
>= 18 years of age
In good general health as evidenced by medical history

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 2 and 100 years old?

Where in United States

National Institutes of Health Clinical CenterBethesda, United StatesContact: Patricia E AlcivarTaking people

About the trial

What the trial wants to find out

The proposed study aims to evaluate, investigate, and follow-up patients suffering from acute and chronic liver disease. The study will focus on understanding diseases affecting the liver.

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Patients participating in the study will first undergo a routine check-up as an outpatient. They will be asked to provide blood and urine samples for laboratory testing and will undergo an ultrasound of the liver. Ultrasound examinations use sound waves to determine the size and texture of the liver. After the initial visit subjects will be requested to follow-up once a year at the outpatient department for a similar check-up.

Additional tests may be requested throughout the study to provide information for other research studies and individual consent will be requested. These tests may include liver biopsies, skin biopsies, and / or specialized blood, plasma, and lymphocyte examinations.

Subjects that qualify for medications presently being studied may be offered the opportunity to benefit from experimental therapy....