Studying Heart Muscle Energy Use in People With Heart Failure
Uses MRI scanning to measure heart energy use in adults with heart failure.
Plain-language title generated from the registry record
Registry title: Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
Key facts
- Where
- Baltimore, United StatesSee the site
Where in United States
- Johns Hopkins Medical InstitutionsBaltimore, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Johns Hopkins University
- Trial code
- NCT00181259
- Record updated
- 9 March 2026
- Original description
The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.Read full original descriptionShow less
In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress
The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.
Inclusion: age > 18 years; Healthy subjects: no history of heart disease; Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) <40%; Left ventricular hypertrophy: wall thickness >1.2cm; Coronary artery disease: >50% coronary lesion or positive stress test.
Exclusion: contraindication to MRI.