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NCT00710177Recruiting

PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn

Prostaglandin G/H Synthase-1 (PTGS1) Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn (PPHN)

Source: ClinicalTrials.gov · Last updated 26 Jan 2026

Brief summary (registry, in English)

The purpose of this study is to determine if normally occurring variations in a specific gene called PTGS-1 are associated with an increased risk of narrowing of the ductus arteriosus from exposure to over-the-counter pain medicines (NSAIDs).

Status (registry)
Recruiting
Study type
Observational
Enrollment
200 (estimated)
First submitted
2 Jul 2008
Start date
Jan 2006
Primary completion date
Dec 2027
Lead sponsor
Medical College of Wisconsin
NCT number
NCT00710177

What you commit to

  • Study type: Observational
  • Planned participants: 200
  • From Jan 2006 to the primary completion date, Dec 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • structural congenital heart disease except presence of patent ductus arteriosus (PDA) or patent foramen ovale
  • congenital anomalies such as diaphragmatic hernia, Potter's syndrome, or pulmonary hypoplasia

Other

  • Patients will be excluded if they are diagnosed with lethal congenital anomalies
  • structural gastrointestinal tract abnormality that could interfere with meconium passage

Who the study is looking for

  • Infants born greater than or equal to 34 weeks gestational age diagnosed with PPHN and normal, healthy infants born greater than or equal to 34 weeks gestational age.

Age in the registry: - to 12 months · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Children's Wisconsin
Coordinator of this site? Confirm its status		MilwaukeeUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.