Studies HIV levels in people on long-term HIV medicines
Checks whether HIV levels stay low in adults taking HIV medicines for a long time.
Plain-language title generated from the registry record
Registry title: Analysis of HIV-1 Replication During Antiretroviral Therapy
Key facts
- Where
- Bethesda, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT00767312, who can take part
Where in United States
- National Institutes of Health Clinical CenterBethesda, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Institute of Allergy and Infectious Diseases (NIAID)
- Trial code
- NCT00767312
- Record updated
- 29 October 2026
- Original description
This study will determine if the level of virus in HIV-infected patients taking antiretroviral medications for prolonged periods decreases or persists at a stable level. It will also examine whether new gene changes (mutations) occur during drug suppression.Read full original descriptionShow less
Analysis of HIV-1 Replication During Antiretroviral Therapy
This study will determine if the level of virus in HIV-infected patients taking antiretroviral medications for prolonged periods decreases or persists at a stable level. It will also examine whether new gene changes (mutations) occur during drug suppression.
HIV-infected patients who are 18 years of age or older, have been enrolled in another NIH protocol, have been suppressed on antiretroviral therapy and have very low levels of virus in their blood may be eligible for this 5-year (or more) study.
Participants come to the NIH Clinical Center about every 6 months for a physical examination, routine and research blood tests and leukapheresis to collect white blood cells for T cell analysis. For leukapheresis, blood is collected through a vein much like donating whole blood, but the blood is directed through a machine that separates and extracts the white cells and returns the rest of the blood components to the patient. Patients may also have an optional third clinic visit each year for another blood draw.
Inclusion: Age greater than or equal to 18 years; HIV infection with documented reactive ELISA and positive western blot; Prior enrollment in 00-I-0110, 97-I-0082 OR patients with long term evaluation at NIH for whom additional sampling will be useful for protocol objectives, including:; Available stored specimens from pretherapy period; Ongoing suppression of viremia with bDNA less than 50 copies/mL, OR; Suppression of viremia to less than 50 copies/mL followed by rebound viremia during therapy; Patients must have a private physician for routine medical care.
Exclusion: Any prospective study subject who has been previously withdrawn from any prior study for inability to comply with study procedures will be considered ineligible for this study.
INCLUSION CRITERIA:.