Early access
Sign in
Taking people in United StatesNo phase

Studies tumor samples from children with several solid cancers

Collects and studies tumor samples from children with solid tumors, observing molecular features only.

Key facts

Who runs it
St. Jude Children's Research Hospital
Where
Memphis, United StatesSee the site
Trial code
Registry title
Molecular Analysis Of Solid Tumors
Status
Recruiting
People taking part
1,000 people, planned
Started
10 Feb 2010
Planned end
30 Sept 2026
Type of study
Observational
Record updated
12 November 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for children and young people up to 25 years old with a suspected or known solid tumor, such as neuroblastoma, osteosarcoma, Ewing sarcoma family of tumors, soft tissue sarcoma or retinoblastoma. Tumor samples are collected for lab research.

Age
Up to 25 years old at enrollment.
Sex
All sexes can join.
Disease stage
A suspected or known diagnosis of neuroblastoma, osteosarcoma, Ewing sarcoma family of tumors or soft tissue sarcoma, with gross disease that can be removed by surgery. Retinoblastoma if the eye needs to be removed and there is no active treatment or biology protocol for retinoblastoma.

Main reasons for not taking part

  • Known to be Hepatitis B positive
  • Known to be Hepatitis C positive
  • Known to be HIV positive

The registry criteria, word for word

Show all 6 criteriaShow less

Who can take part

  • Must have a suspected or known diagnosis of neuroblastoma, osteosarcoma, Ewing sarcoma family of tumor or soft tissue sarcoma based on the initial diagnostic workup and evidence of gross disease amenable to excision. Specimens may be collected at some or all of the following time points: initial biopsy, bone marrow aspiration procedures, tumor resection, and at time of possible relapse
  • Patients with a diagnosis of retinoblastoma based on initial diagnostic workup and who require enucleation may be enrolled if there is no active therapeutic or biologic protocol for retinoblastoma
  • The patient or his/her legal guardian, as appropriate, must provide written informed consent within 30 days of the removal of the first collection of tissue/bone marrow/blood sample for this protocol
  • The patient is being seen at St. Jude Children's Research Hospital or at a collaborating institution
  • Patients must be less than or equal to 25 years old at the time of enrollment

Who cannot take part

  • Patient is known to be Hepatitis B, Hepatitis C and/or HIV positive

Where in United States

  • St. Jude Children's Research HospitalMemphis, United StatesContact: Sara M. Federico, MDTaking people

About the trial

What the trial wants to find out

This study will prospectively characterize the molecular, cellular and genetic properties of primary and metastatic neuroblastoma, osteosarcoma, retinoblastoma, Ewing sarcoma family of tumors, soft tissue sarcomas, adrenocortical tumors and liver malignancies. These cell isolates will be used for gene expression array analysis, genomic analysis by [SNP] single nucleotide polymorphism chip, array [CGH] comparative genomic hybridization and next generation sequencing, and [TEM] transmission electron microscopy analysis. Additionally cell lines and orthotopic xenografts will be created from the obtained tumor specimens.

Read full original descriptionShow less

The specificity of TCRs will be examined by comparing paired TCR from peripheral blood and tumor infiltrating CD4+ and CD8+ T cells. Epigenetic studies will be performed looking at the methylation profile of these cells and to investigate the anti-tumor T cell response both pre- and post-PD1 inhibition.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Molecular Analysis Of Solid Tumors
Plain-language title
Studies tumor samples from children with several solid cancersGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
12 November 2025