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NCT01065454TerminatedPhase 2

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Randomized, Double Blind, Placebo Controlled, Parallel Group, Multi-center Study to Evaluate the Hemodynamic Effects of Riociguat (BAY 63-2521) as Well as Safety and Kinetics in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Source: ClinicalTrials.gov · Last updated 20 Aug 2026

Brief summary (registry, in English)

The aim of this study is to assess whether increasing oral doses of Riociguat are safe and improve the well-being, symptoms and outcome in patients with pulmonary hypertension associated with left ventricular systolic dysfunction

Status (registry)
Terminated
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
202 (actual)
First submitted
8 Feb 2010
Start date
14 Apr 2010
Primary completion date
6 Jun 2012
Lead sponsor
Bayer
NCT number
NCT01065454
EU CT number
2023-507001-34-00
EudraCT number
2009-015878-35

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Types of pulmonary hypertension other than group 2.1 of Dana Point Classification

Who the study is looking for

  • Male and female patients with symptomatic pulmonary hypertension due to left ventricular systolic dysfunction despite optimized heart failure therapy

Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (78)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
-InnsbruckAustriaUnknown status
-ViennaAustriaUnknown status
-HerstonAustraliaUnknown status
-MelbourneAustraliaUnknown status
-SydneyAustraliaUnknown status
-AalstBelgiumUnknown status
-BrusselsBelgiumUnknown status
-GhentBelgiumUnknown status
-LeuvenBelgiumUnknown status
-EdmontonCanadaUnknown status
-MontrealCanadaUnknown status
-QuébecCanadaUnknown status
-VancouverCanadaUnknown status
-GenevaSwitzerlandUnknown status
-LuganoSwitzerlandUnknown status
-ZurichSwitzerlandUnknown status
-BeijingChinaUnknown status
-ShanghaiChinaUnknown status
-BrnoCzechiaUnknown status
-OlomoucCzechiaUnknown status
-PragueCzechiaUnknown status
-AugsburgGermanyUnknown status
-CologneGermanyUnknown status
-ErfurtGermanyUnknown status
-GreifswaldGermanyUnknown status
-HeidelbergGermanyUnknown status
-Aarhus NDenmarkUnknown status
-A CoruñaSpainUnknown status
-BarcelonaSpainUnknown status
-MadridSpainUnknown status
-MajadahondaSpainUnknown status
-MurciaSpainUnknown status
-PalmaSpainUnknown status
-ValenciaSpainUnknown status
-BronFranceUnknown status
-LilleFranceUnknown status
-NantesFranceUnknown status
-PessacFranceUnknown status
-RouenFranceUnknown status
-ToulouseFranceUnknown status
-CambridgeUnited KingdomUnknown status
-LondonUnited KingdomUnknown status
-NaplesItalyUnknown status
-PaviaItalyUnknown status
-Arakawa-kuJapanUnknown status
-HigashiibarakiJapanUnknown status
-Kita-ku, OsakaJapanUnknown status
-KusatsuJapanUnknown status
-NagoyaJapanUnknown status
-ŌgakiJapanUnknown status
-OsakaJapanUnknown status
-SendaiJapanUnknown status
-SetoJapanUnknown status
-Shinjuku-KuJapanUnknown status
-SuitaJapanUnknown status
-SuntoJapanUnknown status
-TanabeJapanUnknown status
-TsuJapanUnknown status
-AmsterdamNetherlandsUnknown status
-NijmegenNetherlandsUnknown status
-BydgoszczPolandUnknown status
-GdanskPolandUnknown status
-WarsawPolandUnknown status
-SingaporeSingaporeUnknown status
-BaltimoreUnited StatesUnknown status
-BostonUnited StatesUnknown status
-CincinnatiUnited StatesUnknown status
-FairfieldUnited StatesUnknown status
-Falls ChurchUnited StatesUnknown status
-Iowa CityUnited StatesUnknown status
-Los AngelesUnited StatesUnknown status
-MiamiUnited StatesUnknown status
-MilwaukeeUnited StatesUnknown status
-RochesterUnited StatesUnknown status
-San DiegoUnited StatesUnknown status
-St LouisUnited StatesUnknown status
-TorranceUnited StatesUnknown status
-WestminsterUnited StatesUnknown status

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This page is information, not medical advice. Discuss any trial with your doctor.